4rr4: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367==

~~The entry~~ 4rr4 is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4rr4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RR4 OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RR4 FirstGlance].

~~Authors~~: ~~Zhu~~, L., ~~Ren~~, X., ~~Zhu~~, J.~~, Li, H~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=3V1:2-CHLORO-N-[3-(4-{[(2Z)-2-CYANO-3-CYCLOPROPYL-3-HYDROXYPROP-2-ENOYL]AMINO}PHENOXY)PHENYL]-4-METHYL-1,3-THIAZOLE-5-CARBOXAMIDE'>3V1</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </td></tr>

~~Description~~: ~~Crystal structure~~ of ~~human dihydroorotate dehydrogenase~~ (~~DHODH~~) ~~with DH03A367~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rr4 OCA], [http://pdbe.org/4rr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rr4 RCSB], [http://www.ebi.ac.uk/pdbsum/4rr4 PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

== Disease ==

[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>

== Function ==

[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.

== References ==

__TOC__

</StructureSection>

[[Category: Li, H]]

[[Category: Ren, X]]

[[Category: Zhu, J]]

~~[[Category: Ren, X]]~~

[[Category: Zhu, L]]

[[Category: Fmn binding]]

[[Category: Mitochondria inner membrane]]

[[Category: Oxidoreductase]]

[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367==
+<StructureSection load='4rr4' size='340' side='right' caption='[[4rr4]], [[Resolution|resolution]] 2.38&Aring;' scene=''>
-The entry 4rr4 is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4rr4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4RR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4RR4 FirstGlance]. <br>
-Authors: Zhu, L., Ren, X., Zhu, J., Li, H.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3V1:2-CHLORO-N-[3-(4-{[(2Z)-2-CYANO-3-CYCLOPROPYL-3-HYDROXYPROP-2-ENOYL]AMINO}PHENOXY)PHENYL]-4-METHYL-1,3-THIAZOLE-5-CARBOXAMIDE'>3V1</scene>, <scene name='pdbligand=FMN:FLAVIN+MONONUCLEOTIDE'>FMN</scene>, <scene name='pdbligand=ORO:OROTIC+ACID'>ORO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Dihydroorotate_dehydrogenase_(quinone) Dihydroorotate dehydrogenase (quinone)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.3.5.2 1.3.5.2] </span></td></tr>
-Description: Crystal structure of human dihydroorotate dehydrogenase (DHODH) with DH03A367
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4rr4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4rr4 OCA], [http://pdbe.org/4rr4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4rr4 RCSB], [http://www.ebi.ac.uk/pdbsum/4rr4 PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Disease ==
+[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Defects in DHODH are the cause of postaxial acrofacial dysostosis (POADS) [MIM:[http://omim.org/entry/263750 263750]]; also known as Miller syndrome. POADS is characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the posterior elements of the limbs, coloboma of the eyelids and supernumerary nipples. POADS is a very rare disorder: only 2 multiplex families, each consisting of 2 affected siblings born to unaffected, nonconsanguineous parents, have been described among a total of around 30 reported cases.<ref>PMID:19915526</ref>
+== Function ==
+[[http://www.uniprot.org/uniprot/PYRD_HUMAN PYRD_HUMAN]] Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Li, H]]
+[[Category: Ren, X]]
 [[Category: Zhu, J]]
-[[Category: Ren, X]]
 [[Category: Zhu, L]]
+[[Category: Fmn binding]]
+[[Category: Mitochondria inner membrane]]
+[[Category: Oxidoreductase]]
+[[Category: Oxidoreductase-oxidoreductase inhibitor complex]]