5e8f: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Structure of Fully modified geranylgeranylated PDE6C Peptide in complex with PDE6D==

~~The entry~~ 5e8f is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5e8f]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8F OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E8F FirstGlance].

~~Authors~~: ~~Fansa~~, E.K., ~~OReilly, N~~.J., ~~Ismail~~, S.A., ~~Wittinghofer, A~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=GER:GERAN-8-YL+GERAN'>GER</scene></td></tr>

<tr id='NonStdRes'><td class="sblockLbl">[[Non-Standard_Residue|NonStd Res:]]</td><td class="sblockDat"><scene name='pdbligand=CMT:O-METHYLCYSTEINE'>CMT</scene></td></tr>

~~Description~~: ~~Structure~~ of ~~Fully modified geranylgeranylated PDE6C Peptide in complex with PDE6D~~

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e8f OCA], [http://pdbe.org/5e8f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e8f RCSB], [http://www.ebi.ac.uk/pdbsum/5e8f PDBsum]</td></tr>

[[Category: ~~Oreilly~~, ~~N.J~~]]

</table>

[[Category: Ismail, S.A]]

== Disease ==

[[http://www.uniprot.org/uniprot/PDE6C_HUMAN PDE6C_HUMAN]] Progressive cone dystrophy;Achromatopsia. The disease is caused by mutations affecting the gene represented in this entry.

== Function ==

[[http://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).

__TOC__

</StructureSection>

[[Category: 3',5'-cyclic-GMP phosphodiesterase]]

[[Category: Fansa, E K]]

[[Category: Ismail, S A]]

[[Category: Reilly, N J.O]]

[[Category: Wittinghofer, A]]

[[Category: ~~Fansa, E.K~~]]

[[Category: Geranylgeranyl]]

[[Category: Hydrolase]]

[[Category: Immunoglobulin-like beta sandwitch fold]]

[[Category: Prenyl binding protein]]

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-'''Unreleased structure'''
+==Structure of Fully modified geranylgeranylated PDE6C Peptide in complex with PDE6D==
+<StructureSection load='5e8f' size='340' side='right' caption='[[5e8f]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
-The entry 5e8f is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5e8f]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5E8F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5E8F FirstGlance]. <br>
-Authors: Fansa, E.K., OReilly, N.J., Ismail, S.A., Wittinghofer, A.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GER:GERAN-8-YL+GERAN'>GER</scene></td></tr>
+<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMT:O-METHYLCYSTEINE'>CMT</scene></td></tr>
-Description: Structure of Fully modified geranylgeranylated PDE6C Peptide in complex with PDE6D
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-GMP_phosphodiesterase 3',5'-cyclic-GMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.35 3.1.4.35] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5e8f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5e8f OCA], [http://pdbe.org/5e8f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5e8f RCSB], [http://www.ebi.ac.uk/pdbsum/5e8f PDBsum]</span></td></tr>
-[[Category: Oreilly, N.J]]
+</table>
-[[Category: Ismail, S.A]]
+== Disease ==
+[[http://www.uniprot.org/uniprot/PDE6C_HUMAN PDE6C_HUMAN]] Progressive cone dystrophy;Achromatopsia. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[[http://www.uniprot.org/uniprot/PDE6D_HUMAN PDE6D_HUMAN]] Acts as a GTP specific dissociation inhibitor (GDI). Increases the affinity of ARL3 for GTP by several orders of magnitude and does so by decreasing the nucleotide dissociation rate. Stabilizes Arl3-GTP by decreasing the nucleotide dissociation (By similarity).
+__TOC__
+</StructureSection>
+[[Category: 3',5'-cyclic-GMP phosphodiesterase]]
+[[Category: Fansa, E K]]
+[[Category: Ismail, S A]]
+[[Category: Reilly, N J.O]]
 [[Category: Wittinghofer, A]]
-[[Category: Fansa, E.K]]
+[[Category: Geranylgeranyl]]
+[[Category: Hydrolase]]
+[[Category: Immunoglobulin-like beta sandwitch fold]]
+[[Category: Prenyl binding protein]]