4wvm: Difference between revisions
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''' | ==Stonustoxin structure== | ||
<StructureSection load='4wvm' size='340' side='right' caption='[[4wvm]], [[Resolution|resolution]] 3.10Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4wvm]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Synanceia_horrida Synanceia horrida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4WVM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4WVM FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4wvm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4wvm OCA], [http://pdbe.org/4wvm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4wvm RCSB], [http://www.ebi.ac.uk/pdbsum/4wvm PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[Category: | [[http://www.uniprot.org/uniprot/STXA_SYNHO STXA_SYNHO]] This lethal (towards mice) toxin induces hemolytic activities due to its ability to form pores in the cell membrane, elicits potent hypotension which is endothelium-dependent and appears to be mediated by the nitric oxide pathway and activation of potassium channels, displays edema-inducing activities, increases vascular permeability, induces endothelium-dependent vasorelaxation of isolated rat aorta, induces platelet aggregation, is myotoxic and interferes irreversibly with neuromuscular function.<ref>PMID:1790672</ref> <ref>PMID:8079369</ref> <ref>PMID:9271089</ref> [[http://www.uniprot.org/uniprot/STXB_SYNHO STXB_SYNHO]] This lethal (towards mice) toxin induces hemolytic activities due to its ability to form pores in the cell membrane, elicits potent hypotension which is endothelium-dependent and appears to be mediated by the nitric oxide pathway and activation of potassium channels, displays edema-inducing activities, increases vascular permeability, induces endothelium-dependent vasorelaxation of isolated rat aorta, induces platelet aggregation, is myotoxic and interferes irreversibly with neuromuscular function.<ref>PMID:1790672</ref> <ref>PMID:8079369</ref> <ref>PMID:9271089</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Synanceia horrida]] | |||
[[Category: Ellisdon, A M]] | |||
[[Category: McGowan, S]] | |||
[[Category: Panjikar, S]] | [[Category: Panjikar, S]] | ||
[[Category: | [[Category: Whisstock, J C]] | ||
[[Category: | [[Category: Cytolysin]] | ||
[[Category: | [[Category: Macpf cdc]] | ||
[[Category: Membrane attack complex]] | |||
[[Category: Perforin cholesterol dependent]] | |||
[[Category: Pry]] | |||
[[Category: Spry]] | |||
[[Category: Thioredoxin focal adhesion targeting]] | |||
[[Category: Toxin]] | |||
[[Category: Venom]] | |||
