5d7p: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of human Sirt2 in complex with ADPR and EX-243==

~~The entry~~ 5d7p is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5d7p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D7P FirstGlance]. <br>

~~Authors~~: ~~Rumpf~~, T., ~~Gerhardt~~, S., ~~Einsle~~, O., ~~Jung~~, M.

</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene>, <scene name='pdbligand=OCZ:(1S)-6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-+CARBOXAMIDE'>OCZ</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7p OCA], [http://pdbe.org/5d7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d7p RCSB], [http://www.ebi.ac.uk/pdbsum/5d7p PDBsum]</span></td></tr>

~~Description:~~

</table>

[[~~Category~~: ~~Unreleased Structures~~]]

== Function ==

[[Category: ~~Rumpf~~, T]]

[[http://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN]] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Einsle, O]]

[[Category: Gerhardt, S]]

[[Category: Jung, M]]

[[Category: ~~Einsle~~, O]]

[[Category: Rumpf, T]]

[[Category: Deacylase]]

[[Category: Human sirtuin 2]]

[[Category: Hydrolase]]

[[Category: Inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of human Sirt2 in complex with ADPR and EX-243==
+<StructureSection load='5d7p' size='340' side='right' caption='[[5d7p]], [[Resolution|resolution]] 1.76&Aring;' scene=''>
-The entry 5d7p is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5d7p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D7P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D7P FirstGlance]. <br>
-Authors: Rumpf, T., Gerhardt, S., Einsle, O., Jung, M.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=AR6:[(2R,3S,4R,5R)-5-(6-AMINOPURIN-9-YL)-3,4-DIHYDROXY-OXOLAN-2-YL]METHYL+[HYDROXY-[[(2R,3S,4R,5S)-3,4,5-TRIHYDROXYOXOLAN-2-YL]METHOXY]PHOSPHORYL]+HYDROGEN+PHOSPHATE'>AR6</scene>, <scene name='pdbligand=OCZ:(1S)-6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-+CARBOXAMIDE'>OCZ</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d7p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d7p OCA], [http://pdbe.org/5d7p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d7p RCSB], [http://www.ebi.ac.uk/pdbsum/5d7p PDBsum]</span></td></tr>
-Description:
+</table>
-[[Category: Unreleased Structures]]
+== Function ==
-[[Category: Rumpf, T]]
+[[http://www.uniprot.org/uniprot/SIR2_HUMAN SIR2_HUMAN]] NAD-dependent protein deacetylase, which deacetylates internal lysines on histone and non-histone proteins. Deacetylates 'Lys-40' of alpha-tubulin. Involved in the control of mitotic exit in the cell cycle, probably via its role in the regulation of cytoskeleton. Deacetylates PCK1, opposing proteasomal degradation. Deacetylates 'Lys-310' of RELA.<ref>PMID:12620231</ref> <ref>PMID:12697818</ref> <ref>PMID:21081649</ref> <ref>PMID:21726808</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Einsle, O]]
 [[Category: Gerhardt, S]]
 [[Category: Jung, M]]
-[[Category: Einsle, O]]
+[[Category: Rumpf, T]]
+[[Category: Deacylase]]
+[[Category: Human sirtuin 2]]
+[[Category: Hydrolase]]
+[[Category: Inhibitor complex]]