Sandbox 77: Difference between revisions

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~~<Structure load='4iar' size='300' frame='true' align='right' caption='5-HT1B Receptor' scene='Insert optional scene name here' />~~

~~==Serotonin Receptors==~~

== General Function ==

5-HT, ~~serotonin~~, receptors are found on the membrane of neurons in the central nervous system and peripheral nervous system. These receptors allow for the body to respond to serotonin and regulate many biological pathways. Serotonin, also known as 5 hydroxytryptamine, is an endogenous neurotransmitter made from tryptophan and is largely found in the gastrointestinal tract. 5-HT receptors are classified into 7 different subfamilies (5-HT1, 5-HT2, 5-HT3, etc.) by signaling mechanisms and homology of structure. All 5-HT receptors are known to have G-protein linked pathways except for the 5-HT3 receptor which acts as an ion channel. (Wang, et al. 2013).

5-HT, Serotonin, receptors are found on the membrane of neurons in the central nervous system and peripheral nervous system. These receptors allow for the body to respond to serotonin and regulate many biological pathways. Serotonin, also known as 5 hydroxytryptamine, is an endogenous neurotransmitter made from tryptophan and is largely found in the gastrointestinal tract. 5-HT receptors are classified into 7 different subfamilies (5-HT1, 5-HT2, 5-HT3, etc.) by signaling mechanisms and homology of structure. All 5-HT receptors are known to have G-protein linked pathways except for the 5-HT3 receptor which acts as an ion channel. (Wang, et al. 2013).

== Structural highlights/Specific Function of 5-HT1B==

~~<Structure load='4ib4' size='300' frame='true' align='right' caption='5-HT2B Receptor' scene='Insert optional scene name here' />~~

The 5-HT1B receptor couples to G-protein alpha subunits Gi and Go. In the central nervous system, this receptor is an inhibitory presynaptic receptor that can alter the release of serotonin, as well as other neurotransmitters, from the presynaptic neuron. The structure of this receptor includes 7 transmembrane alpha-helices in its center. The N-terminal tail of 5-HT1B is close to the ligand binding pocket suggesting some interaction with its ligand. The orthosteric, unmodulated, binding pocket is characterized as a cavity formed from residues of the 3rd, 5th, 6th, and 7th alpha helices and the 2nd extracellular loop. (Wang, et al. 2013)

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== Structural highlights/Specific Function of 5-HT3==

The 5-HT3 receptor is a pentameric cation-selective ion channel and plays a role in neuronal excitation to release neurotransmitters from the postsynaptic neuron. 5-HT3 is usually comprised of subunits A or A and B which can result in a homopentameric receptor or a heteropentameric receptor respectively. 5-HT3 is a transmembrane channel that is stimulated to open state by the interaction of the receptor with serotonin in the extracellular space. The binding site is comprised of six loops from two adjacent subunits.The transmembrane region is comprised of multiple alpha helical structures and mediates ion flow and ion specificity. ~~<Structure load='4pir' size='300' frame='true' align='right' caption='5-HT3 Receptor' scene='Insert optional scene name here' />~~ Sodium and Potassium ions are allowed to pass through the 5-HT3 receptor pore. This receptor is involved in the transfer of information to the gastrointestinal tract which makes it a target of drugs which repress vomiting and irritable bowel syndrome.

The 5-HT3 receptor is a pentameric cation-selective ion channel and plays a role in neuronal excitation to release neurotransmitters from the postsynaptic neuron. 5-HT3 is usually comprised of subunits A or A and B which can result in a homopentameric receptor or a heteropentameric receptor respectively. 5-HT3 is a transmembrane channel that is stimulated to open state by the interaction of the receptor with serotonin in the extracellular space. The binding site is comprised of six loops from two adjacent subunits.The transmembrane region is comprised of multiple alpha helical structures and mediates ion flow and ion specificity. Sodium and Potassium ions are allowed to pass through the 5-HT3 receptor pore. This receptor is involved in the transfer of information to the gastrointestinal tract which makes it a target of drugs which repress vomiting and irritable bowel syndrome.

Sandbox 77: Difference between revisions

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@@ Line 1: / Line 1: @@
-<Structure load='4iar' size='300' frame='true' align='right' caption='5-HT1B Receptor' scene='Insert optional scene name here' />
-==Serotonin Receptors==
 == General Function ==
--HT, serotonin, receptors are found on the membrane of neurons in the central nervous system and peripheral nervous system. These receptors allow for the body to respond to serotonin and regulate many biological pathways. Serotonin, also known as 5 hydroxytryptamine, is an endogenous neurotransmitter made from tryptophan and is largely found in the gastrointestinal tract. 5-HT receptors are classified into 7 different subfamilies (5-HT1, 5-HT2, 5-HT3, etc.) by signaling mechanisms and homology of structure. All 5-HT receptors are known to have G-protein linked pathways except for the 5-HT3 receptor which acts as an ion channel. (Wang, et al. 2013).
+<Structure load='4pir' size='300' frame='true' align='right' caption='5-HT3 Receptor' scene='Insert optional scene name here' />
+-HT, Serotonin, receptors are found on the membrane of neurons in the central nervous system and peripheral nervous system. These receptors allow for the body to respond to serotonin and regulate many biological pathways. Serotonin, also known as 5 hydroxytryptamine, is an endogenous neurotransmitter made from tryptophan and is largely found in the gastrointestinal tract. 5-HT receptors are classified into 7 different subfamilies (5-HT1, 5-HT2, 5-HT3, etc.) by signaling mechanisms and homology of structure. All 5-HT receptors are known to have G-protein linked pathways except for the 5-HT3 receptor which acts as an ion channel. (Wang, et al. 2013).
 == Structural highlights/Specific Function of 5-HT1B==
-<Structure load='4ib4' size='300' frame='true' align='right' caption='5-HT2B Receptor' scene='Insert optional scene name here' />
 The 5-HT1B receptor couples to G-protein alpha subunits Gi and Go. In the central nervous system, this receptor is an inhibitory presynaptic receptor that can alter the release of serotonin, as well as other neurotransmitters, from the presynaptic neuron. The structure of this receptor includes 7 transmembrane alpha-helices in its center. The N-terminal tail of 5-HT1B is close to the ligand binding pocket suggesting some interaction with its ligand. The orthosteric, unmodulated, binding pocket is characterized as a cavity formed from residues of the 3rd, 5th, 6th, and 7th alpha helices and the 2nd extracellular loop. (Wang, et al. 2013)
@@ Line 12: / Line 10: @@
 == Structural highlights/Specific Function of 5-HT3==
-The 5-HT3 receptor is a pentameric cation-selective ion channel and plays a role in neuronal excitation to release neurotransmitters from the postsynaptic neuron. 5-HT3 is usually comprised of subunits A or A and B which can result in a homopentameric receptor or a heteropentameric receptor respectively. 5-HT3 is a transmembrane channel that is stimulated to open state by the interaction of the receptor with serotonin in the extracellular space. The binding site is comprised of six loops from two adjacent subunits.The transmembrane region is comprised of multiple alpha helical structures and mediates ion flow and ion specificity.  <Structure load='4pir' size='300' frame='true' align='right' caption='5-HT3 Receptor' scene='Insert optional scene name here' /> Sodium and Potassium ions are allowed to pass through the 5-HT3 receptor pore. This receptor is involved in the transfer of information to the gastrointestinal tract which makes it a target of drugs which repress vomiting and irritable bowel syndrome.
+The 5-HT3 receptor is a pentameric cation-selective ion channel and plays a role in neuronal excitation to release neurotransmitters from the postsynaptic neuron. 5-HT3 is usually comprised of subunits A or A and B which can result in a homopentameric receptor or a heteropentameric receptor respectively. 5-HT3 is a transmembrane channel that is stimulated to open state by the interaction of the receptor with serotonin in the extracellular space. The binding site is comprised of six loops from two adjacent subunits.The transmembrane region is comprised of multiple alpha helical structures and mediates ion flow and ion specificity. Sodium and Potassium ions are allowed to pass through the 5-HT3 receptor pore. This receptor is involved in the transfer of information to the gastrointestinal tract which makes it a target of drugs which repress vomiting and irritable bowel syndrome.