Sandbox 4465: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
==Calmodulin== | ==Calmodulin== | ||
<StructureSection load='2bcx' size='340' side='right' caption='Homo sapien calmodulin showing Ca+2' scene=''> | <StructureSection load='2bcx' size='340' side='right' caption='Homo sapien calmodulin showing Ca+2' scene=''> | ||
Calmodulin (CaM), short for calcium modulated protein, is a small calcium binding protein with a three dimensional structure. Calcium is the most abundant essential mineral in the human diet for proper functioning of neurons to forming strong bones and can also serve as a second messenger for enzymes and proteins. Calmodulin has been known to be involved in various Ca2+ - dependent signal transduction pathways, can act as a Ca2+ detector, and has been involved with regulated protein-kinases. | |||
Its importance can be exemplified by the fact that the protein has been known to be highly conserved in eukaryotes. Highly conserved structures that do not undergo significant evolutionary changes imply that the structure is mandatory for cell or organism survival and that any mutations in the genetic sequence that codes for the protein would be deleterious. The function of calmodulin is typically studied using yeast as a model organism. This is done for a variety of reasons, including the fact that yeast has a fully annotated genome with human homologues for genes associated with their ion channels, yeast is fast | Its importance can be exemplified by the fact that the protein has been known to be highly conserved in eukaryotes. Highly conserved structures that do not undergo significant evolutionary changes imply that the structure is mandatory for cell or organism survival and that any mutations in the genetic sequence that codes for the protein would be deleterious. The function of calmodulin is typically studied using yeast as a model organism. This is done for a variety of reasons, including the fact that yeast has a fully annotated genome with human homologues for genes associated with their ion channels, yeast is fast | ||
