Chaperonin: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Michal Harel (talk | contribs) No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| Line 2: | Line 2: | ||
{{STRUCTURE_1pcq| PDB=1pcq | SIZE=400| SCENE=Chaperonin/Groel_groes_comnplex/1 |right|CAPTION=GroEL/GroES complex with ADP, AlF3, Mg+2 and K+ ions, [[1pcq]] }} | {{STRUCTURE_1pcq| PDB=1pcq | SIZE=400| SCENE=Chaperonin/Groel_groes_comnplex/1 |right|CAPTION=GroEL/GroES complex with ADP, AlF3, Mg+2 and K+ ions, [[1pcq]] }} | ||
<StructureSection load='1pcq' size='350' side='right' caption='GroEL/GroES complex with ADP, AlF3, Mg+2 and K+ ions (PDB entry [[1pcq]])' scene=''> | |||
'''Chaperonins''' (CPN) are oligomeric proteins that mediate the folding of polypeptide chains. Group I CPN are found in bacteria, chloroplasts and mitochondria. For an introductory overview, see [http://en.wikipedia.org/wiki/Chaperonins Chaperonins in Wikipedia]. | '''Chaperonins''' (CPN) are oligomeric proteins that mediate the folding of polypeptide chains. Group I CPN are found in bacteria, chloroplasts and mitochondria. For an introductory overview, see [http://en.wikipedia.org/wiki/Chaperonins Chaperonins in Wikipedia]. | ||
| Line 30: | Line 8: | ||
The most characterized CPN are in the GroEL/GroES complex from ''Escherichia coli'' and CPN60/CPN10 from ''Thermus thermophilus''. The larger subunit (GroEL, CPN60) contains 3 domains. The apical domain is the one which binds the substrate. Group II CPNs are found in eukaryotic cytosol and archaea. Thermosome is a CPN complex found in archaea. CCT is a CPN complex found in eukarya. | The most characterized CPN are in the GroEL/GroES complex from ''Escherichia coli'' and CPN60/CPN10 from ''Thermus thermophilus''. The larger subunit (GroEL, CPN60) contains 3 domains. The apical domain is the one which binds the substrate. Group II CPNs are found in eukaryotic cytosol and archaea. Thermosome is a CPN complex found in archaea. CCT is a CPN complex found in eukarya. | ||
See also [[Chaperones]]. | See also [[Chaperones]]. | ||
</StructureSection> | |||
== 3D Structures of Chaperonin == | == 3D Structures of Chaperonin == | ||
| Line 117: | Line 95: | ||
**[[3j1f]] - AtTherm β subunit + ATP – Cryo EM <br /> | **[[3j1f]] - AtTherm β subunit + ATP – Cryo EM <br /> | ||
**[[3aq1]] – Therm – ''Methanococcoides burtonii''<br /> | **[[3aq1]] – Therm – ''Methanococcoides burtonii''<br /> | ||
**[[1q2v]], [[1q3r]] – TkTherm α subunit (mutant) – Thermococcus KS-1<br /> | **[[1q2v]], [[1q3r]] – TkTherm α subunit (mutant) – ''Thermococcus KS-1''<br /> | ||
**[[1q3q]] - TkTherm α subunit (mutant) + AMP-PNP<br /> | **[[1q3q]] - TkTherm α subunit (mutant) + AMP-PNP<br /> | ||
**[[1q3s]] - TkTherm α subunit (mutant) + ADP<br /> | **[[1q3s]] - TkTherm α subunit (mutant) + ADP<br /> | ||
| Line 123: | Line 101: | ||
**[[1lep]] – CPN-10 – ''Mycobacterium leprae'' | **[[1lep]] – CPN-10 – ''Mycobacterium leprae'' | ||
}} | }} | ||
== References == | |||
<references/> | |||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
