Sandbox 77: Difference between revisions
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== Structural highlights/Specific Function of 5-HT2B== | == Structural highlights/Specific Function of 5-HT2B== | ||
The <scene name='71/716548/5-ht2b_receptor/1'>5-HT2B receptor</scene> is important in utilizing serotonin signals to encourage proper development and continuing function of the cardiovascular system. Overexpression of 5-HT2B has been linked to congestive heart failure.<ref>Wiebke J, Schymura Y, Novoyatleva T, Kojonazarov B, Boehm M, Wietelmann A, Luitel H, Murmann K, Krompiec DR, Tretyn A, Pullamsetti SS, Weissmann N, Seeger W, Ghofrani HA, Schermuly RT. | The <scene name='71/716548/5-ht2b_receptor/1'>5-HT2B receptor</scene> is important in utilizing serotonin signals to encourage proper development and continuing function of the cardiovascular system. Overexpression of 5-HT2B has been linked to congestive heart failure.<ref>Wiebke J, Schymura Y, Novoyatleva T, Kojonazarov B, Boehm M, Wietelmann A, Luitel H, Murmann K, Krompiec DR, Tretyn A, Pullamsetti SS, Weissmann N, Seeger W, Ghofrani HA, Schermuly RT. 5-HT2B Receptor Antagonists Inhibit Fibrosis and Protect from RV Heart Failure. Biomed Res Int. 2015; 2015: 438403. PMID:4312574 [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4312574]</ref> 5-HT2B utilizes the alpha Gq protein pathway which triggers intracellular cGMP production through activation of nictric-oxidase synthase (NOS).<ref>Nebigil, Etienne, Schaerlinger, Hickel, Launay, Maroteaux "Developmentally Regulated Serotonin 5-HT2B Receptors.” [http://www.sciencedirect.com/science/article/pii/S0736574801000223 DOI: 10.1016/S0736-5748(01)00022-3]</ref> This receptor is also known for being the target of the drug LSD, which has similar structure to serotonin. <ref> Berumen LC, Rodriguez A, Miledi R, Gracia-Alcocer G. Serotonin Receptors in Hippocampus. ScientificWorldJournal. 2012;2012:823493. Epub 2012 May 2. PMID:3353568 doi: 10.1100/2012/823493.</ref> The structure of this receptor is much like that of 5-HT1B. It has the characteristic 7 alpha helices and the N-terminus sticks out into extracellular space. <ref name="one" /> | ||
== Structural highlights/Specific Function of 5-HT3== | == Structural highlights/Specific Function of 5-HT3== | ||
The <scene name='71/716548/5-ht3_receptor/1'>5-HT3 receptor</scene> is a pentameric cation-selective ion channel and plays a role in neuronal excitation to release neurotransmitters from the postsynaptic neuron. 5-HT3 is usually comprised of subunits A or A and B which can result in a homopentameric receptor or a heteropentameric receptor respectively. 5-HT3 is a transmembrane channel that is stimulated to open state by the interaction of the receptor with serotonin in the extracellular space. The binding site is comprised of six loops from two adjacent subunits.The transmembrane region is comprised of multiple alpha helical structures and mediates ion flow and ion specificity. Sodium and Potassium ions are allowed to pass through the 5-HT3 receptor pore. This receptor is involved in the transfer of information to the gastrointestinal tract which makes it a target of drugs which repress vomiting and irritable bowel syndrome.<ref> Thompson AJ, Lummis SCR. | The <scene name='71/716548/5-ht3_receptor/1'>5-HT3 receptor</scene> is a pentameric cation-selective ion channel and plays a role in neuronal excitation to release neurotransmitters from the postsynaptic neuron. 5-HT3 is usually comprised of subunits A or A and B which can result in a homopentameric receptor or a heteropentameric receptor respectively. 5-HT3 is a transmembrane channel that is stimulated to open state by the interaction of the receptor with serotonin in the extracellular space. The binding site is comprised of six loops from two adjacent subunits.The transmembrane region is comprised of multiple alpha helical structures and mediates ion flow and ion specificity. Sodium and Potassium ions are allowed to pass through the 5-HT3 receptor pore. This receptor is involved in the transfer of information to the gastrointestinal tract which makes it a target of drugs which repress vomiting and irritable bowel syndrome.<ref> Thompson AJ, Lummis SCR. 5-HT3 Receptors. Curr Pharm Des. 2006; 12(28): 3615–3630. PMID:2664614 [http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2664614/]</ref> | ||
==References== | ==References== | ||
<references /> | <references /> | ||
==Proteopedia Page Contributors and Editors== | ==Proteopedia Page Contributors and Editors== | ||
