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== 5-HT3a Receptor== | == 5-HT3a Receptor== | ||
<StructureSection load='5-ht3a.pdb' size='650' side='right' caption='5-HT3a receptor' scene='71/716487/Default/1'> | <StructureSection load='5-ht3a.pdb' size='650' side='right' caption='5-HT3a receptor' scene='71/716487/Default/1'> | ||
5-Hydroxytryptamine receptors, commonly known as 5-HT receptors, bind with the neurotransmitter serotonin. There are seven families of 5-HT receptors (5-HT1- 5-HT7), all of which function as G-protein-coupled receptors with the exception of the 5-HT3 group. This third group uses ligand-gated ion channels. This article focuses specifically on the 5-HT3 receptors and how its structure contributes to its function. These functions include: altering anxiety level, influencing the vomiting reflex, increase of intestinal secretion and gastric motility. Although the exact structural model of the 5-HT3 receptor has not be definitively identified, through the process of homology modeling, using acetylcholine binding protein as a template, a structure has been inferred. | |||
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