Sandbox8999: Difference between revisions

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===Individual Molecule===

An individual clathrin molecule is composed of three heavy chains, each being attached to a light chain. This structure is often referred to as a triskelion shape.<ref name="harrison" /> The heavy chains of clathrin are made of an amino-terminal, a beta-propellor domain containing multiple repeats of the WD40 binding motif, alpha-helical zig-zags close to 30 amino acids in length, a lengthened alpha-helix where the threefold contacts, and a carboxy-terminal.<ref name="harrison" /> The aforementioned zig-zags are what create the “leg” looking structure of the triskelion.<ref name="harrison" /> Part of the heavy chain is designated to bind to the light chains~~, of which there are two variations in mammals~~.<ref name="harrison" /> The heavy chain and light chain bind through one long alpha helix towards the center of the protein.<ref name="harrison" />

An individual clathrin molecule is composed of three heavy chains, each being attached to a light chain. This structure is often referred to as a triskelion shape.<ref name="harrison" /> The heavy chains of clathrin are made of an amino-terminal, a beta-propellor domain containing multiple repeats of the WD40 binding motif, alpha-helical zig-zags close to 30 amino acids in length, a lengthened alpha-helix where the threefold contacts, and a carboxy-terminal.<ref name="harrison" /> The aforementioned zig-zags are what create the “leg” looking structure of the triskelion.<ref name="harrison" /> Part of the heavy chain is designated to bind to the light chains.<ref name="harrison" /> The heavy chain and light chain bind through one long alpha helix towards the center of the protein.<ref name="harrison" />

[[Image:LatticeStructure.png |frame| a) Clathrin monomer with labeled heavy and light chains b) Clathrin monomers forming a basic lattice structure.<ref name="pearse">PMID: 1063406</ref> Clathrin is made of individual triskelion components that come together to form the cage-like structure of clathrin.<ref name="crowther" /> Each vertex is composed of a triskelion leg.<ref name="crowther" /> Although there are various packing models for clathrin cage assembly, the overall theme is multiple triskelions coming together to form the cage like structure.<ref name="crowther" />]]

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 ===Individual Molecule===
-An individual clathrin molecule is composed of three heavy chains, each being attached to a light chain. This structure is often referred to as a triskelion shape.<ref name="harrison" /> The heavy chains of clathrin are made of an amino-terminal, a beta-propellor domain containing multiple repeats of the WD40 binding motif, alpha-helical zig-zags close to 30 amino acids in length, a lengthened alpha-helix where the threefold contacts, and a carboxy-terminal.<ref name="harrison" /> The aforementioned zig-zags are what create the “leg” looking structure of the triskelion.<ref name="harrison" /> Part of the heavy chain is designated to bind to the light chains, of which there are two variations in mammals.<ref name="harrison" /> The heavy chain and light chain bind through one long alpha helix towards the center of the protein.<ref name="harrison" />
+An individual clathrin molecule is composed of three heavy chains, each being attached to a light chain. This structure is often referred to as a triskelion shape.<ref name="harrison" /> The heavy chains of clathrin are made of an amino-terminal, a beta-propellor domain containing multiple repeats of the WD40 binding motif, alpha-helical zig-zags close to 30 amino acids in length, a lengthened alpha-helix where the threefold contacts, and a carboxy-terminal.<ref name="harrison" /> The aforementioned zig-zags are what create the “leg” looking structure of the triskelion.<ref name="harrison" /> Part of the heavy chain is designated to bind to the light chains.<ref name="harrison" /> The heavy chain and light chain bind through one long alpha helix towards the center of the protein.<ref name="harrison" />
 [[Image:LatticeStructure.png |frame| a) Clathrin monomer with labeled heavy and light chains b) Clathrin monomers forming a basic lattice structure.<ref name="pearse">PMID: 1063406</ref> Clathrin is made of individual triskelion components that come together to form the cage-like structure of clathrin.<ref name="crowther" /> Each vertex is composed of a triskelion leg.<ref name="crowther" /> Although there are various packing models for clathrin cage assembly, the overall theme is multiple triskelions coming together to form the cage like structure.<ref name="crowther" />]]