Sandbox 420: Difference between revisions

Line 43:

==Memory==

CB1 receptors are also highly concentrated in the hippocampus. The hippocampus is a region of the brain involved with learning and memory <ref name ="g"/>. The relatively high density of CB1 receptors in the hippocampus is responsible for the memory-altering effects of THC and other cannabinoids ~~(8)~~.

CB1 receptors are also highly concentrated in the hippocampus. The hippocampus is a region of the brain involved with learning and memory <ref name ="g"/>. The relatively high density of CB1 receptors in the hippocampus is responsible for the memory-altering effects of THC and other cannabinoids <ref> PMID: 22385967 </ref>.

==Motor Control==

CB1 receptors are also located in the basal ganglia, a region of the brain responsible for the coordination of movement ~~(5)~~. The binding of endocannabinoids has been shown to play a critical role in fine motor control. Specifically, it has been shown that CB1 receptor binding is decreased in patients with neurodegenerative diseases such as Parkinson’s and Huntington’s disease. In contrast, CB1 receptors have a lesser influence on gross motor control due to the lower concentration of receptors in the cerebellum, which is responsible for coordinating gross motor control ~~(5)~~.

CB1 receptors are also located in the basal ganglia, a region of the brain responsible for the coordination of movement <ref name="review"/>. The binding of endocannabinoids has been shown to play a critical role in fine motor control. Specifically, it has been shown that CB1 receptor binding is decreased in patients with neurodegenerative diseases such as Parkinson’s and Huntington’s disease. In contrast, CB1 receptors have a lesser influence on gross motor control due to the lower concentration of receptors in the cerebellum, which is responsible for coordinating gross motor control <ref name="review"/>.

==Control of Appetite==

Line 52:

==Regulation of Anxiety==

CB1 receptors are responsible for mediating the anti-anxiety effects of cannabinoids, like THC. In low doses, cannabinoids reduce anxiety; however, high doses of cannabinoids act to increase anxiety <ref name="toxic" />~~(4)~~. This is one reason why synthetic cannabinoids like K2, an extremely potent synthetic cannabinoids, produces the harmful side effect of extreme anxiety.

CB1 receptors are responsible for mediating the anti-anxiety effects of cannabinoids, like THC. In low doses, cannabinoids reduce anxiety; however, high doses of cannabinoids act to increase anxiety <ref name="toxic" />. This is one reason why synthetic cannabinoids like K2, an extremely potent synthetic cannabinoids, produces the harmful side effect of extreme anxiety.

Sandbox 420: Difference between revisions

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 43: / Line 43: @@
 ==Memory==
-CB1 receptors are also highly concentrated in the hippocampus. The hippocampus is a region of the brain involved with learning and memory <ref name ="g"/>. The relatively high density of CB1 receptors in the hippocampus is responsible for the memory-altering effects of THC and other cannabinoids (8).
+CB1 receptors are also highly concentrated in the hippocampus. The hippocampus is a region of the brain involved with learning and memory <ref name ="g"/>. The relatively high density of CB1 receptors in the hippocampus is responsible for the memory-altering effects of THC and other cannabinoids <ref> PMID: 22385967 </ref>.
 ==Motor Control==
-CB1 receptors are also located in the basal ganglia, a region of the brain responsible for the coordination of movement (5). The binding of endocannabinoids has been shown to play a critical role in fine motor control. Specifically, it has been shown that CB1 receptor binding is decreased in patients with neurodegenerative diseases such as Parkinson’s and Huntington’s disease. In contrast, CB1 receptors have a lesser influence on gross motor control due to the lower concentration of receptors in the cerebellum, which is responsible for coordinating gross motor control (5).
+CB1 receptors are also located in the basal ganglia, a region of the brain responsible for the coordination of movement <ref name="review"/>. The binding of endocannabinoids has been shown to play a critical role in fine motor control. Specifically, it has been shown that CB1 receptor binding is decreased in patients with neurodegenerative diseases such as Parkinson’s and Huntington’s disease. In contrast, CB1 receptors have a lesser influence on gross motor control due to the lower concentration of receptors in the cerebellum, which is responsible for coordinating gross motor control <ref name="review"/>.
 ==Control of Appetite==
@@ Line 52: / Line 52: @@
 ==Regulation of Anxiety==
-CB1 receptors are responsible for mediating the anti-anxiety effects of cannabinoids, like THC. In low doses, cannabinoids reduce anxiety; however, high doses of cannabinoids act to increase anxiety <ref name="toxic" />(4). This is one reason why synthetic cannabinoids like K2, an extremely potent synthetic cannabinoids, produces the harmful side effect of extreme anxiety.
+CB1 receptors are responsible for mediating the anti-anxiety effects of cannabinoids, like THC. In low doses, cannabinoids reduce anxiety; however, high doses of cannabinoids act to increase anxiety <ref name="toxic" />. This is one reason why synthetic cannabinoids like K2, an extremely potent synthetic cannabinoids, produces the harmful side effect of extreme anxiety.