Sandbox 77: Difference between revisions

Lysergic Acid Diethylamide, more commonly known as LSD, is a potent hallucinogen and is derived from ergotamine, an ergopeptine whose structural skeleton is contained in a diverse range of alkaloids. LSD acts as a non-selective 5-HT receptor agonist, meaning it can bind with equal affinity to two or more sub-types of receptors. LSD actively binds in the orthosteric binding pocket to both the 5-HT1B and 5HT-2B receptors, suggesting a similar chemical structure and function between the two receptor families <ref name = "one" />. The docking is stabilized by hydrogen bonding between the amino group of the 5-membered ring of LSD and the threonine residue of the 5-HT1B receptor, in a similar fashion that 5-HT would bind to said receptor.