Sandbox 77: Difference between revisions

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== Structural highlights/Specific Function of 5-HT1B==

The <scene name='71/716548/5-ht1b/1'>5-HT1B receptor</scene> couples to G-protein alpha subunits Gi and Go. In the central nervous system, this receptor is an inhibitory presynaptic receptor that can alter the release of serotonin, as well as other neurotransmitters, from the presynaptic neuron. The structure of this receptor includes <scene name='71/716548/5-ht1b/2'>7 transmembrane alpha-helices</scene>.<scene name='71/716548/5-ht1b/3'>The N-terminal tail</scene> of 5-HT1B is close to the ligand binding pocket suggesting some interaction with its ligand. <scene name='71/716548/5-ht1b/5'>The ligand binding pocket</scene>, also called the orthosteric binding pocket, is characterized as a cavity formed from residues of the 3rd, 5th, 6th, and 7th alpha helices and the 2nd extracellular loop. <ref name = "one" />

The <scene name='71/716548/5-ht1b/1'>5-HT1B receptor</scene> couples to G-protein alpha subunits Gi and Go. In the central nervous system, this receptor is an inhibitory presynaptic receptor that can alter the release of serotonin, as well as other neurotransmitters, from the presynaptic neuron. The structure of this receptor includes <scene name='71/716548/5-ht1b/6'>7 transmembrane alpha-helices</scene>.<scene name='71/716548/5-ht1b/3'>The N-terminal tail</scene> of 5-HT1B is close to the ligand binding pocket suggesting some interaction with its ligand. <scene name='71/716548/5-ht1b/5'>The ligand binding pocket</scene>, also called the orthosteric binding pocket, is characterized as a cavity formed from residues of the 3rd, 5th, 6th, and 7th alpha helices and the 2nd extracellular loop. <ref name = "one" />

== Structural highlights/Specific Function of 5-HT2B==

Sandbox 77: Difference between revisions

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 == Structural highlights/Specific Function of 5-HT1B==
-The <scene name='71/716548/5-ht1b/1'>5-HT1B receptor</scene> couples to G-protein alpha subunits Gi and Go. In the central nervous system, this receptor is an inhibitory presynaptic receptor that can alter the release of serotonin, as well as other neurotransmitters, from the presynaptic neuron. The structure of this receptor includes <scene name='71/716548/5-ht1b/2'>7 transmembrane alpha-helices</scene>.<scene name='71/716548/5-ht1b/3'>The N-terminal tail</scene> of 5-HT1B is close to the ligand binding pocket suggesting some interaction with its ligand. <scene name='71/716548/5-ht1b/5'>The ligand binding pocket</scene>, also called the orthosteric binding pocket, is characterized as a cavity formed from residues of the 3rd, 5th, 6th, and 7th alpha helices and the 2nd extracellular loop. <ref name = "one" />
+The <scene name='71/716548/5-ht1b/1'>5-HT1B receptor</scene> couples to G-protein alpha subunits Gi and Go. In the central nervous system, this receptor is an inhibitory presynaptic receptor that can alter the release of serotonin, as well as other neurotransmitters, from the presynaptic neuron. The structure of this receptor includes <scene name='71/716548/5-ht1b/6'>7 transmembrane alpha-helices</scene>.<scene name='71/716548/5-ht1b/3'>The N-terminal tail</scene> of 5-HT1B is close to the ligand binding pocket suggesting some interaction with its ligand. <scene name='71/716548/5-ht1b/5'>The ligand binding pocket</scene>, also called the orthosteric binding pocket, is characterized as a cavity formed from residues of the 3rd, 5th, 6th, and 7th alpha helices and the 2nd extracellular loop. <ref name = "one" />
 == Structural highlights/Specific Function of 5-HT2B==