Clathrin JMU: Difference between revisions
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===The Canonical Pathway=== | ===The Canonical Pathway=== | ||
Classical endocytosis involving clathrin-coated pits and clathrin-coated vesicles is referred to as the canonical clathrin pathway (Figure 3).<ref name="harrison" /> Canonical clathrin-dependent pathways involve the uptake of transferrin (Tf) by transferrin receptor (TfR) and the uptake of LDL by LDL receptors (LDLR).<ref name="harrison" /> Early studies showed that LDL epidermal growth factor (Tf) bound to their specific receptors could be endocytosed within the same vesicle.<ref name="harrison" /> The receptors for these molecules are composed of tails on their cytoplasmic side that contain sequences, which determine cargo sorting and also signal for clathrin to bind.<ref name="harrison" /> Clathrin then coats these vesicles and endocytosis occurs.<ref name="harrison" /> Other pathways, such as reuptake of neurotransmitters into the synaptic cleft, are seen to have similar mechanisms to canonical clathrin pathways.<ref name="harrison" /> | Classical endocytosis involving clathrin-coated pits and clathrin-coated vesicles is referred to as the canonical clathrin pathway (Figure 3).<ref name="harrison" /> Canonical clathrin-dependent pathways involve the uptake of transferrin (Tf) by transferrin receptor (TfR) and the uptake of LDL by LDL receptors (LDLR).<ref name="harrison" /> Early studies showed that LDL and epidermal growth factor (Tf) bound to their specific receptors could be endocytosed within the same vesicle.<ref name="harrison" /> The receptors for these molecules are composed of tails on their cytoplasmic side that contain sequences, which determine cargo sorting and also signal for clathrin to bind.<ref name="harrison" /> Clathrin then coats these vesicles and endocytosis occurs.<ref name="harrison" /> Other pathways, such as reuptake of neurotransmitters into the synaptic cleft, are seen to have similar mechanisms to canonical clathrin pathways.<ref name="harrison" /> | ||
[[Image:Endocytosis.gif |frame| '''Figure 3'''. Formation and dissociation of a canonical, endocytitic clathrin-coated pit.<ref name="harrison" />]] | [[Image:Endocytosis.gif |frame| '''Figure 3'''. Formation and dissociation of a canonical, endocytitic clathrin-coated pit.<ref name="harrison" />]] | ||
