1aoo: Difference between revisions
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|PDB= 1aoo |SIZE=350|CAPTION= <scene name='initialview01'>1aoo</scene> | |PDB= 1aoo |SIZE=350|CAPTION= <scene name='initialview01'>1aoo</scene> | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=AG:SILVER ION'>AG</scene> | |LIGAND= <scene name='pdbligand=AG:SILVER+ION'>AG</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY= | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1aoo FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1aoo OCA], [http://www.ebi.ac.uk/pdbsum/1aoo PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1aoo RCSB]</span> | |||
}} | }} | ||
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[[Category: Narula, S S.]] | [[Category: Narula, S S.]] | ||
[[Category: Peterson, C W.]] | [[Category: Peterson, C W.]] | ||
[[Category: copper detoxification]] | [[Category: copper detoxification]] | ||
[[Category: metal-thiolate cluster]] | [[Category: metal-thiolate cluster]] | ||
[[Category: metallothionein]] | [[Category: metallothionein]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 18:44:33 2008'' | ||
Revision as of 15:44, 30 March 2008
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| Ligands: | AG | ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
AG-SUBSTITUTED METALLOTHIONEIN FROM SACCHAROMYCES CEREVISIAE, NMR, MINIMIZED AVERAGE STRUCTURE
Overview
3D solution structural calculations for yeast silver(I)-substituted metallothionein (MT) and native copper(I) MT were completed using experimentally determined NOE and dihedral angle constraints, in conjunction with experimentally derived metal-to-Cys connectivities for AgMT which were assumed identical for CuMT. For the first 40 residues in both structures, the polypeptide backbone wraps around the metal cluster in two large parallel loops separated by a deep cleft containing the metal cluster. Minor differences between the two structures include differences in hydrogen bonds and the orientation of the N-terminus with the overall protein volume conserved to within 6.5%.
About this Structure
1AOO is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.
Reference
3D solution structure of copper and silver-substituted yeast metallothioneins., Peterson CW, Narula SS, Armitage IM, FEBS Lett. 1996 Jan 22;379(1):85-93. PMID:8566237
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