Cyclohydrolase

spinqualitylabelsall models Structure of GTP cyclohydrolase I pentamer complex with 8-oxo-GTP (stick model) and Zn+2 ion (grey) (PDB code 1wuq). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function • GTP cyclohydrolase I catalyzes the conversion of GTP to 7,8-dihydronepterin triphosphate. GCH I is part of the folate and biopterin biosynthesis • GTP cyclohydrolase II catalyzes the conversion of GTP to formate, diphosphate and diamino-hydroxy-phosphoribosylamino pyrimidine. GCH II is part of riboflavin metabolism. • IMP cyclohydrolase catalyzes the conversion of IMP to formido-phosphosibosyl imidazole carboxamide. ICH is part of the purine biosynthesis • Methenyltetrahydromethanopterin cyclohydrolase catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin. MCH is part of the folate biosynthesis Methylenetetrahydrofolate dehydrogenase/cyclohydrolase catalyzes the interconversion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate in mitochondria of mammalian cells. Disease Mutations in GTP cyclohydrolase I are associated with malignant phenylketonuria, hyperphenylalaninemia and DOPA-responsive dystonia. Structural highlights GCH I GTP binding pocket iw at the trimer interface.

3D structures of cyclohydrolase

Updated on 16-December-2015

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• GTP cyclohydrolase I
  • 1gtp – EcGCH I – Escherichia coli
    
  • 3d1t – NgGCH IB + Zn – Neisseria gonorrhoeae
    
  • 3d2o – NgGCH IB + Mn
    
  • 1fb1 – hGCH I + Zn – human
    
  • 1wm9 – TtGCH I + Zn – Thermus thermophilus
    
• GTP cyclohydrolase I complexes
  • 1a8r, 1a9c, 1n3r, 1n3t, 1n3s – EcGCH I (mutant) + GTP
    
  • 4du6 – GCH I + GTP – Yersinia pseudotuberculosis
    
  • 1fbx – EcGCH I + Zn
    
  • 1wuq, 1wur – TtGCH I + Zn + 8-oxo-GTP
    
  • 1is7 – rGCH I + GCH feedback regulatory protein - rat
    
  • 1is8 – rGCH I + GCH feedback regulatory protein + Zn
    
  • 1wpl – rGCH I + GCH feedback regulatory protein + Zn + dihydrobiopterin
    
• GTP cyclohydrolase II
  • 2bz1 – EcGCH II + Zn
    
  • 2bz0 – EcGCH II + Zn + phosphomethylphosphonic acid guanylate
    
• GTP cyclohydrolase III
  • 2qv6 – GCH III + GTP + Ca – Methanocaldococcus jannaschii
    
• IMP cyclohydrolase
  • 2ntm – MtICH – Methanothermobacter thermoautotrophicus
    
  • 2ntk – MtICH + IMP
    
  • 2ntl – MtICH + AICAR
    
• Methenyltetrahydromethanopterin cyclohydrolase
  • 1qlm – MCH – Methanopyrus kandleri
    
  • 4fio – MCH – Methanobrevibacter ruminatium
    
  • 4gvr – AfMCH – Archaeoglobus fulgidus
    
  • 4gvq – AfMCH + tetrahydromethanopterin
    
  • 4gvs – AfMCH + N5-formyl-tetrahydromethanopterin
    
• Methylenetetrahydrofolate dehydrogenase/cyclohydrolase
  • 2c2x, 2c2y – MCH – Mycobacterium tuberculosis
    
  • 1a4i – hMCH + NADP
    
  • 1dig, 1dia, 1dib, 1dig – hMCH + NADP + inhibitor
    
• Phosphoribosyl-ATP cyclohydrolase
  • 1zps – MtPCH + Cd
    

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