5eun: Difference between revisions
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''' | ==The Crystal Structure of Human Kynurenine Aminotransferase II, PLP-bound form, at 1.83 A== | ||
<StructureSection load='5eun' size='340' side='right' caption='[[5eun]], [[Resolution|resolution]] 1.82Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5eun]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EUN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EUN FirstGlance]. <br> | |||
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=LLP:(2S)-2-AMINO-6-[[3-HYDROXY-2-METHYL-5-(PHOSPHONOOXYMETHYL)PYRIDIN-4-YL]METHYLIDENEAMINO]HEXANOIC+ACID'>LLP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5eun FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5eun OCA], [http://pdbe.org/5eun PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5eun RCSB], [http://www.ebi.ac.uk/pdbsum/5eun PDBsum]</span></td></tr> | |||
</table> | |||
[[Category: | == Function == | ||
[[Category: | [[http://www.uniprot.org/uniprot/AADAT_HUMAN AADAT_HUMAN]] Transaminase with broad substrate specificity. Has transaminase activity towards aminoadipate, kynurenine, methionine and glutamate. Shows activity also towards tryptophan, aspartate and hydroxykynurenine. Accepts a variety of oxo-acids as amino-group acceptors, with a preference for 2-oxoglutarate, 2-oxocaproic acid, phenylpyruvate and alpha-oxo-gamma-methiol butyric acid. Can also use glyoxylate as amino-group acceptor (in vitro).<ref>PMID:18620547</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Church, W B]] | |||
[[Category: Hanrahan, J R]] | |||
[[Category: Harrop, S J]] | |||
[[Category: Jeffries, C M]] | |||
[[Category: Kwan, A]] | [[Category: Kwan, A]] | ||
[[Category: | [[Category: Nadvi, N A]] | ||
[[Category: Nematollahi, A]] | [[Category: Nematollahi, A]] | ||
[[Category: | [[Category: Sun, G]] | ||
[[Category: | [[Category: Kynurenine aminotransferase ii]] | ||
[[Category: Llp]] | |||
[[Category: Transferase]] | |||
Revision as of 13:58, 16 December 2015
The Crystal Structure of Human Kynurenine Aminotransferase II, PLP-bound form, at 1.83 A
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