5fpd: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Structure of heat shock-related 70kDA protein 2 with small-molecule ligand pyrazine-2-carboxamide (AT513) in an alternate binding site.==

~~The entry~~ 5fpd is ~~ON HOLD until sometime in~~ the ~~future~~

== Structural highlights ==

<table><tr><td colspan='2'>[[5fpd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPD OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FPD FirstGlance].

~~Authors~~: ~~JHOTI~~, H., ~~LUDLOW~~, R.F., ~~PATEL~~, S., ~~SAINI, H~~.K., ~~TICKLE, I~~.J.~~, VERDONK, M~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=PZA:PYRAZINE-2-CARBOXAMIDE'>PZA</scene></td></tr>

~~Description~~: ~~Structure~~ of ~~heat shock-related 70kDA protein 2~~ with ~~small-molecule ligand pyrazine-2~~-~~carboxamide (AT513) in an alternate binding site~~.

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpd OCA], [http://pdbe.org/5fpd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fpd RCSB], [http://www.ebi.ac.uk/pdbsum/5fpd PDBsum]</td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

[[Category: ~~Tickle~~, ~~I.J~~]]

== Function ==

[[Category: Saini, H.K]]

[[http://www.uniprot.org/uniprot/HSP72_HUMAN HSP72_HUMAN]] In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.

__TOC__

</StructureSection>

[[Category: Jhoti, H]]

[[Category: Ludlow, R F]]

[[Category: Patel, S]]

[[Category: Saini, H K]]

[[Category: Tickle, I J]]

[[Category: Verdonk, M]]

[[Category: ~~Ludlow, R.F~~]]

[[Category: Alternate binding site]]

[[Category: ~~Patel, S~~]]

[[Category: At513]]

[[Category: ~~Jhoti, H~~]]

[[Category: Chaperone]]

[[Category: Fragment screening]]

[[Category: Heat shock]]

[[Category: Heat shock-related protein]]

[[Category: Hsp70]]

[[Category: Hspa2]]

[[Category: Protein-ligand complex]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Structure of heat shock-related 70kDA protein 2 with small-molecule ligand pyrazine-2-carboxamide (AT513) in an alternate binding site.==
+<StructureSection load='5fpd' size='340' side='right' caption='[[5fpd]], [[Resolution|resolution]] 1.97&Aring;' scene=''>
-The entry 5fpd is ON HOLD  until sometime in the future
+== Structural highlights ==
+<table><tr><td colspan='2'>[[5fpd]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPD OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FPD FirstGlance]. <br>
-Authors: JHOTI, H., LUDLOW, R.F., PATEL, S., SAINI, H.K., TICKLE, I.J., VERDONK, M.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PZA:PYRAZINE-2-CARBOXAMIDE'>PZA</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fp5|5fp5]], [[5fp6|5fp6]], [[5fpe|5fpe]], [[5fpm|5fpm]], [[5fpn|5fpn]], [[5fpo|5fpo]], [[5fpr|5fpr]], [[5fps|5fps]], [[5fpt|5fpt]], [[5fpy|5fpy]]</td></tr>
-Description: Structure of heat shock-related 70kDA protein 2 with small-molecule ligand pyrazine-2-carboxamide (AT513) in an alternate binding site.
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fpd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpd OCA], [http://pdbe.org/5fpd PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fpd RCSB], [http://www.ebi.ac.uk/pdbsum/5fpd PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Tickle, I.J]]
+== Function ==
-[[Category: Saini, H.K]]
+[[http://www.uniprot.org/uniprot/HSP72_HUMAN HSP72_HUMAN]] In cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation and mediate the folding of newly translated polypeptides in the cytosol as well as within organelles. These chaperones participate in all these processes through their ability to recognize nonnative conformations of other proteins. They bind extended peptide segments with a net hydrophobic character exposed by polypeptides during translation and membrane translocation, or following stress-induced damage.
+__TOC__
+</StructureSection>
+[[Category: Jhoti, H]]
+[[Category: Ludlow, R F]]
+[[Category: Patel, S]]
+[[Category: Saini, H K]]
+[[Category: Tickle, I J]]
 [[Category: Verdonk, M]]
-[[Category: Ludlow, R.F]]
+[[Category: Alternate binding site]]
-[[Category: Patel, S]]
+[[Category: At513]]
-[[Category: Jhoti, H]]
+[[Category: Chaperone]]
+[[Category: Fragment screening]]
+[[Category: Heat shock]]
+[[Category: Heat shock-related protein]]
+[[Category: Hsp70]]
+[[Category: Hspa2]]
+[[Category: Protein-ligand complex]]