Stepler sandbox STAT3: Difference between revisions
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== Structure == | == Structure == | ||
The STAT3 protein is composed of several <scene name='71/714950/Stat3_helix_turn_helix/1'>Helix Turn Helix</scene> structures and its quaternary structure consists of two STAT3 proteins <scene name='71/714950/Stat3_dimer/1'>dimerized</scene> with themselves. <ref>PMID:9671298</ref> | The STAT3 protein is composed of several <scene name='71/714950/Stat3_helix_turn_helix/1'>Helix Turn Helix</scene> structures and its quaternary structure consists of two STAT3 proteins <scene name='71/714950/Stat3_dimer/1'>dimerized</scene> with themselves. <ref>PMID:9671298</ref> | ||
== Regulation == | == Regulation == | ||
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== DNA-Protein Interactions == | == DNA-Protein Interactions == | ||
The <scene name='71/714950/Stat3_dimer_and_dna/1'>STAT3 protein interacts with DNA</scene> by binding to the major groove of | The <scene name='71/714950/Stat3_dimer_and_dna/1'>STAT3 protein dimer interacts with DNA</scene> by wrapping around it. <scene name='71/714950/Dna-binding_domain/4'>Stat3 interacts with DNA</scene> by binding to the major groove of it. STAT3 (along with other STAT family members) bind to specific DNA sequences. <ref>PMID:11050435</ref> STAT3 has a binding domain with sequences like TTN(5-6)AA. <scene name='71/714950/Dna-binding_domain/3'>This stretch</scene> is then what interacts with the STAT3 protein. As shown in the scene, the DNA is bound by the protein in its major groove. | ||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||
