Cyclohydrolase

spinqualitylabelsall models Structure of GTP cyclohydrolase I pentamer complex with GTP (PDB code 1n3r). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Cyclohydrolase is an enzyme which catalyzes the reversible cyclization or the ring opening of a purine ring. • GTP cyclohydrolase I catalyzes the conversion of GTP to 7,8-dihydronepterin triphosphate. GCH I is part of the folate and biopterin biosynthesis • GTP cyclohydrolase II catalyzes the conversion of GTP to formate, diphosphate and diamino-hydroxy-phosphoribosylamino pyrimidine. GCH II is part of riboflavin metabolism. • IMP cyclohydrolase catalyzes the conversion of IMP to formido-phosphosibosyl imidazole carboxamide. ICH is part of the purine biosynthesis • Methenyltetrahydromethanopterin cyclohydrolase catalyzes the conversion of methenyltetrahydromethanopterin to formyl-tetrahydromethanopterin. MCH is part of the folate biosynthesis Methylenetetrahydrofolate dehydrogenase/cyclohydrolase catalyzes the interconversion of 5,10-methylenetetrahydrofolate and 10-formyltetrahydrofolate in mitochondria of mammalian cells. Disease Mutations in GTP cyclohydrolase I are associated with malignant phenylketonuria, hyperphenylalaninemia and DOPA-responsive dystonia. Structural highlights GCH I GTP binding pocket at the trimer interface.

3D structures of cyclohydrolase

Updated on 22-December-2015

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• GTP cyclohydrolase I
  • 1gtp – EcGCH I – Escherichia coli
    
  • 3d1t – NgGCH IB + Zn – Neisseria gonorrhoeae
    
  • 3d2o – NgGCH IB + Mn
    
  • 1fb1 – hGCH I + Zn – human
    
  • 1wm9 – TtGCH I + Zn – Thermus thermophilus
    
• GTP cyclohydrolase I complexes
  • 1a8r, 1a9c, 1n3r, 1n3t, 1n3s – EcGCH I (mutant) + GTP
    
  • 4du6 – GCH I + GTP – Yersinia pseudotuberculosis
    
  • 1fbx – EcGCH I + Zn
    
  • 1wuq, 1wur – TtGCH I + Zn + 8-oxo-GTP
    
  • 1is7 – rGCH I + GCH feedback regulatory protein - rat
    
  • 1is8 – rGCH I + GCH feedback regulatory protein + Zn
    
  • 1wpl – rGCH I + GCH feedback regulatory protein + Zn + dihydrobiopterin
    
• GTP cyclohydrolase II
  • 2bz1 – EcGCH II + Zn
    
  • 2bz0 – EcGCH II + Zn + phosphomethylphosphonic acid guanylate
    
• GTP cyclohydrolase III
  • 2qv6 – GCH III + GTP + Ca – Methanocaldococcus jannaschii
    
• IMP cyclohydrolase
  • 2ntm – MtICH – Methanothermobacter thermoautotrophicus
    
  • 2ntk – MtICH + IMP
    
  • 2ntl – MtICH + AICAR
    
• Methenyltetrahydromethanopterin cyclohydrolase
  • 1qlm – MCH – Methanopyrus kandleri
    
  • 4fio – MCH – Methanobrevibacter ruminatium
    
  • 4gvr – AfMCH – Archaeoglobus fulgidus
    
  • 4gvq – AfMCH + tetrahydromethanopterin
    
  • 4gvs – AfMCH + N5-formyl-tetrahydromethanopterin
    
• Methylenetetrahydrofolate dehydrogenase/cyclohydrolase
  • 2c2x, 2c2y – MCH – Mycobacterium tuberculosis
    
  • 1a4i – hMCH + NADP
    
  • 1dig, 1dia, 1dib, 1dig – hMCH + NADP + inhibitor
    
• Phosphoribosyl-ATP cyclohydrolase
  • 1zps – MtPCH + Cd
    

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Michal Harel, Alexander Berchansky