4xdx: Difference between revisions
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''' | ==The crystal structure of soluble human interleukin 8 expressed in Pichia pastoris== | ||
<StructureSection load='4xdx' size='340' side='right' caption='[[4xdx]], [[Resolution|resolution]] 0.95Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4xdx]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XDX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XDX FirstGlance]. <br> | |||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xdx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xdx OCA], [http://pdbe.org/4xdx PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xdx RCSB], [http://www.ebi.ac.uk/pdbsum/4xdx PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[Category: | [[http://www.uniprot.org/uniprot/IL8_HUMAN IL8_HUMAN]] IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively.<ref>PMID:2145175</ref> <ref>PMID:2212672</ref> <ref>PMID:11978786</ref> | ||
[[Category: Pompeu, Y | == References == | ||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Jakoncic, J J]] | |||
[[Category: Ostrov, D A]] | |||
[[Category: Pompeu, Y A]] | |||
[[Category: Alpha beta protein]] | |||
[[Category: Chemokine]] | |||
[[Category: Cytokine]] | |||
[[Category: Il8 fold]] | |||
Revision as of 12:46, 23 December 2015
The crystal structure of soluble human interleukin 8 expressed in Pichia pastoris
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