Elastase

Elastase (ELA) is a chymotrypsin-like protease which breaks down proteins. The ELAs are numbered according to their genes. Panceatic ELA cleaves proteins at the carboxyl-terminal side of small neutral amino acids. It cleaves Ala-Ala and Ala-Gly bonds. For additional details see Serine Proteases.

Relevance

ELA2 (or PMN-ELA) is secreted by neutrophils during inflammation.

Disease

Pulmonary emphysema is caused by the destruction of elastic fibre by elastase. Mutations in ELA2 are linked to the genetic disorder cyclic hematopoeiesis. Neutrophil elastase is involved in the blistering in bullose pemphigoid.

3D structures of elastase

Updated on 11-January-2016

{"openlevels":0}

• MMP12 See Matrix metalloproteinase
• MMP16 See Matrix metalloproteinase
• ELA1
  • 3mty, 3mu0, 3mu1, 3mu4, 3mu5, 3mu8, 3mnb, 3mnc, 3mns, 3mnx, 3mo3, 3mo6, 3mo9, 3moc, 3e3t, 2v0b, 2g4t, 2g4u, 2de8, 2blo, 2blq, 2a7c, 2a7j, 1gvk, 1qnj, 1lvy, 3est, 1est, 2oqu, 3odd, 3odf, 2bdc – pELA1 – pig
    
  • 3hgn – pELA1+peptidyl inhibitor – neutron
    
  • 3hgp, 2cv3, 2bdb, 2bcd, 2h1u, 1mmj, 1h9l, 1nes, 4est, 5est, 8est, 7est, 6est - pELA1+peptidyl inhibitor
    
  • 1fzz – pELA1+ONO-6818
    
  • 1qr3, 1qgf, 1bru, 1hv7, 1btu – pELA1+cyclic inhibitor
    
  • 1okx – pELA1 + scyptolin
    
  • 1e34, 1e35, 1e36, 1e37, 1e38 – pELA1-gamma-lactam
    
  • 1eai – pELA1+Ascaris inhibitor
    
  • 2d26 – pELA1+α-1-antitrypsin
    
  • 1fle – pELA1+elafin
    
  • 1b0e, 1b0f – pELA1+MDL
    
  • 2v35 – pELA1+JM54
    
  • 2iot – pELA1+clavulanic acid
    
  • 2de9 – pELA1+tris
    
  • 1uvo, 1uvp, 1lka, 1lkb – pELA1+ions
    
  • 1gwa – pELA1+I3
    
  • 1uo6, 1c1m – pELA1+Xe
    
  • 1l0z, 1l1g - pELA1+Xe+Br
    
  • 2bb4, 2bd2, 2bd3, 2bd4, 2bd5, 2bd7, 2bd8, 2bd9, 1hax, 1hay, 1haz, 1hb0, 1qix – pELA1+beta-casomorphin-7
    
  • 2bda – pELA1+N-acetyl-NPI
    
  • 1mcv – pELA1+squash inhibitor
    
  • 1bma – pELA1+aminimide
    
  • 1elf, 1elg – pELA1+peptidyl hydroxylamine
    
  • 1eld, 1ele, 1elb, 1ela, 1elc, 2est – pELA1+anilide inhibitor
    
  • 1esa, 1esb – pELA1 intermediate
    
  • 1eas, 1eat, 1eau – pELA1+pyridine inhibitor
    
  • 1inc – pELA1+benzoxazinone
    
  • 1jim, 9est, 8est – pELA1+coumarin derivative
    
  • 2fo9, 2foa, 2fob, 2foc, 2fod, 2foe, 2fof, 2fog, 2foh – pELA1+solvent
    
  • 4k89 – PaELA – Pseudomonas aeruginosa
    
  • 3dbk – PaELA+phophoramidon
    
  • 1u4g – PaELA+HPI
    
  • 1ezm - PaELA
    
  • 1elt – ELA - salmon
    
• ELA2
  • 3q76 – hELA2
    
  • 3q77 – hELA2+dihydropyrimidone inhibitor
    
  • 2z7f – hELA2 peptidase domain +antileukoproteinase
    
  • 2rg3 – hELA2+sulfonic inhibitor
    
  • 1h1b, 1ppg, 1hne – hELA2+inhibitor
    
  • 1ppf – hELA2+ovomucoid
    
  • 1b0f – hELA2+MDL101146
    
  • 4nzl – hELA2 + protein
    
  • 4wvp – hELA2 + activity-based probe
    

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Alexander Berchansky, Guido Hansen, Jaime Prilusky, Michal Harel