4txi: Difference between revisions
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''' | ==Construct of MICAL-1 containing the monooxygenase and calponin homology domains== | ||
<StructureSection load='4txi' size='340' side='right' caption='[[4txi]], [[Resolution|resolution]] 2.31Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4txi]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4TXI OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4TXI FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4txk|4txk]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4txi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4txi OCA], [http://pdbe.org/4txi PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4txi RCSB], [http://www.ebi.ac.uk/pdbsum/4txi PDBsum]</span></td></tr> | |||
[[Category: | </table> | ||
[[Category: Bianchet, M | == Function == | ||
[[Category: | [[http://www.uniprot.org/uniprot/MICA1_MOUSE MICA1_MOUSE]] Monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin. Acts by modifying actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a cytoskeletal regulator that connects NEDD9 to intermediate filaments (By similarity). Also acts as a negative regulator of apoptosis via its interaction with STK38 and STK38L; acts by antagonizing STK38 and STK38L activation by MST1/STK4. | ||
[[Category: | __TOC__ | ||
</StructureSection> | |||
[[Category: Alqassim, S S]] | |||
[[Category: Amzel, L M]] | |||
[[Category: Bianchet, M A]] | |||
[[Category: Calponin homology]] | |||
[[Category: Mical]] | |||
[[Category: Monooxygenase]] | |||
[[Category: Oxidoreductase]] | |||
Revision as of 20:19, 13 January 2016
Construct of MICAL-1 containing the monooxygenase and calponin homology domains
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