5el3: Difference between revisions
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''' | ==Structure of the KH domain of T-STAR== | ||
<StructureSection load='5el3' size='340' side='right' caption='[[5el3]], [[Resolution|resolution]] 1.59Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5el3]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5EL3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5EL3 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5el3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5el3 OCA], [http://pdbe.org/5el3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5el3 RCSB], [http://www.ebi.ac.uk/pdbsum/5el3 PDBsum]</span></td></tr> | |||
[ | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/KHDR3_HUMAN KHDR3_HUMAN]] RNA-binding protein that plays a role in the regulation of alternative splicing and influences mRNA splice site selection and exon inclusion. May play a role as a negative regulator of cell growth. Inhibits cell proliferation. Involved in splice site selection of vascular endothelial growth factor. Induces an increased concentration-dependent incorporation of exon in CD44 pre-mRNA by direct binding to purine-rich exonic enhancer. RNA-binding abilities are down-regulated by tyrosine kinase PTK6. Involved in post-transcriptional regulation of HIV-1 gene expression. Binds preferentially to the 5'-[AU]UAAA-3' motif in vitro.<ref>PMID:10564820</ref> <ref>PMID:11741900</ref> <ref>PMID:15901763</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dominguez, C]] | [[Category: Dominguez, C]] | ||
[[Category: Feracci, M]] | [[Category: Feracci, M]] | ||
[[Category: Protein - rna complexes star proteins kh - domain alternative splicing]] | |||
[[Category: Rna binding protein]] | |||
Revision as of 20:33, 13 January 2016
Structure of the KH domain of T-STAR
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