5fpv: Difference between revisions

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'''Unreleased structure'''
==Crystal structure of human JMJD2A in complex with compound KDOAM20A==
 
<StructureSection load='5fpv' size='340' side='right' caption='[[5fpv]], [[Resolution|resolution]] 2.44&Aring;' scene=''>
The entry 5fpv is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[5fpv]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FPV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FPV FirstGlance]. <br>
Authors: Srikannathasan, V., Gileadi, C., von Delft, F., Arrowsmith, C.H., Bountra, C., Edwards, A., Oppermann, U.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MMK:2-{[(2-{[(E)-2-(DIMETHYLAMINO)ETHENYL](ETHYL)AMINO}-2-OXOETHYL)AMINO]METHYL}PYRIDINE-4-CARBOXYLIC+ACID'>MMK</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5fpl|5fpl]], [[5fpu|5fpu]]</td></tr>
Description: Crystal structure of human JMJD2A in complex with compound KDOAM20A
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fpv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fpv OCA], [http://pdbe.org/5fpv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fpv RCSB], [http://www.ebi.ac.uk/pdbsum/5fpv PDBsum]</span></td></tr>
[[Category: Unreleased Structures]]
</table>
== Function ==
[[http://www.uniprot.org/uniprot/KDM4A_HUMAN KDM4A_HUMAN]] Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref>  Isoform 2: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain.<ref>PMID:16024779</ref> <ref>PMID:16603238</ref> <ref>PMID:21694756</ref> 
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Arrowsmith, C H]]
[[Category: Bountra, C]]
[[Category: Bountra, C]]
[[Category: Arrowsmith, C.H]]
[[Category: Delft, F von]]
[[Category: Edwards, A]]
[[Category: Gileadi, C]]
[[Category: Gileadi, C]]
[[Category: Oppermann, U]]
[[Category: Oppermann, U]]
[[Category: Von Delft, F]]
[[Category: Edwards, A]]
[[Category: Srikannathasan, V]]
[[Category: Srikannathasan, V]]
[[Category: Jmjd2a]]
[[Category: Kdm4a]]
[[Category: Oxidoreductase]]
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