Ets1: Difference between revisions
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== Function == | == Function == | ||
'''Ets1 (E26 Transformation-Specific)''' is a proto-oncogene translation factor. Ets1 contributes to the regulation of cellular differentiation | '''Ets1 (E26 Transformation-Specific)''' is a proto-oncogene translation factor. Ets1 contributes to the regulation of cellular differentiation<ref>PMID:17986575</ref> . | ||
== Disease == | == Disease == | ||
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== Structural highlights == | == Structural highlights == | ||
Ets1 contains an ETS domain which is a helix-turn-helix DNA-binding domain which recognizes the sequence GGAA/T. The ETS domain is flanked by autoinhibitory domains. At the N-terminal, Ets1 contains a pointed domain (PNT) and a MAP kinase phosphorylation domain. PNT domain is related to SAM domains and contains 4 α-helices. | |||
</StructureSection> | </StructureSection> | ||
