4xjm: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a HTS lead compound==

~~The entry~~ 4xjm is ~~ON HOLD until Jan 20 2017~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4xjm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJM OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XJM FirstGlance].

~~Authors~~: ~~Finzel~~, B.C., ~~Dai~~, R.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=41E:3-{1-[(5-ACETYLTHIOPHEN-2-YL)CARBONYL]PIPERIDIN-4-YL}-N-(3-METHOXYPHENYL)PROPANAMIDE'>41E</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4xjl|4xjl]], [[4xjo|4xjo]], [[4xjp|4xjp]]</td></tr>

~~Description~~: ~~Crystal structure~~ of 7,8-diaminopelargonic acid ~~synthase~~ (~~BioA~~) ~~from Mycobacterium tuberculosis, complexed with a HTS lead compound~~

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Adenosylmethionine--8-amino-7-oxononanoate_transaminase Adenosylmethionine--8-amino-7-oxononanoate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.62 2.6.1.62] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xjm OCA], [http://pdbe.org/4xjm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xjm RCSB], [http://www.ebi.ac.uk/pdbsum/4xjm PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/BIOA_MYCTU BIOA_MYCTU]] Catalyzes the reversible transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor. Can also use sinefungin as substrate.<ref>PMID:16984394</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Adenosylmethionine--8-amino-7-oxononanoate transaminase]]

[[Category: Dai, R]]

[[Category: Finzel, B.C]]

[[Category: Finzel, B C]]

[[Category: Inhibitor complex transaminase plp]]

[[Category: Transferase-transferase inhibitor complex]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a HTS lead compound==
+<StructureSection load='4xjm' size='340' side='right' caption='[[4xjm]], [[Resolution|resolution]] 1.60&Aring;' scene=''>
-The entry 4xjm is ON HOLD  until Jan 20 2017
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4xjm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XJM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XJM FirstGlance]. <br>
-Authors: Finzel, B.C., Dai, R.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=41E:3-{1-[(5-ACETYLTHIOPHEN-2-YL)CARBONYL]PIPERIDIN-4-YL}-N-(3-METHOXYPHENYL)PROPANAMIDE'>41E</scene>, <scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xjl|4xjl]], [[4xjo|4xjo]], [[4xjp|4xjp]]</td></tr>
-Description: Crystal structure of 7,8-diaminopelargonic acid synthase (BioA) from Mycobacterium tuberculosis, complexed with a HTS lead compound
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Adenosylmethionine--8-amino-7-oxononanoate_transaminase Adenosylmethionine--8-amino-7-oxononanoate transaminase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.6.1.62 2.6.1.62] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xjm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xjm OCA], [http://pdbe.org/4xjm PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4xjm RCSB], [http://www.ebi.ac.uk/pdbsum/4xjm PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/BIOA_MYCTU BIOA_MYCTU]] Catalyzes the reversible transfer of the alpha-amino group from S-adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor. Can also use sinefungin as substrate.<ref>PMID:16984394</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Adenosylmethionine--8-amino-7-oxononanoate transaminase]]
 [[Category: Dai, R]]
-[[Category: Finzel, B.C]]
+[[Category: Finzel, B C]]
+[[Category: Inhibitor complex transaminase plp]]
+[[Category: Transferase-transferase inhibitor complex]]