5hen: Difference between revisions
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''' | ==Crystal structure of the N-terminus R100L bromodomain mutant of human BRD2== | ||
<StructureSection load='5hen' size='340' side='right' caption='[[5hen]], [[Resolution|resolution]] 1.79Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5hen]] is a 3 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HEN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HEN FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hen FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hen OCA], [http://pdbe.org/5hen PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hen RCSB], [http://www.ebi.ac.uk/pdbsum/5hen PDBsum]</span></td></tr> | |||
</table> | |||
[[ | == Function == | ||
[[http://www.uniprot.org/uniprot/BRD2_HUMAN BRD2_HUMAN]] May play a role in spermatogenesis or folliculogenesis (By similarity). Binds hyperacetylated chromatin and plays a role in the regulation of transcription, probably by chromatin remodeling. Regulates transcription of the CCND1 gene. Plays a role in nucleosome assembly.<ref>PMID:18406326</ref> | |||
[[Category: | == References == | ||
[[Category: | <references/> | ||
__TOC__ | |||
</StructureSection> | |||
[[Category: Arrowsmith, C H]] | |||
[[Category: Bountra, C]] | |||
[[Category: Chiaraluce, R]] | [[Category: Chiaraluce, R]] | ||
[[Category: Consalvi, V]] | [[Category: Consalvi, V]] | ||
[[Category: | [[Category: Delft, F von]] | ||
[[Category: | [[Category: Edwards, A M]] | ||
[[Category: | [[Category: Knapp, S]] | ||
[[Category: Newman, J | [[Category: Lori, C]] | ||
[[Category: Newman, J A]] | |||
[[Category: Pasquo, A]] | |||
[[Category: Tallant, C]] | [[Category: Tallant, C]] | ||
[[Category: Post translational modifications recognition]] | |||
[[Category: Transcription]] | |||
[[Category: Transcription regulation]] | |||
Revision as of 17:28, 20 January 2016
Crystal structure of the N-terminus R100L bromodomain mutant of human BRD2
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