Factor IX: Difference between revisions

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<span style="color:Brown">'''<scene name='Factor_IX/Ixstructure/4'>Factor IX</scene>'''</span> (plasma thromboplastin component, Christmas factor, or hemophilia B factor) is a 57-kDa vitamin K-dependent procoagulant glycoprotein. It is synthesized by the liver hepatocyte as a [[pre-prozymogen]] that requires extensive posttranslational modification<ref>PMID:2169923</ref>. The [[pre-prozymogen]] contains a pre-peptide (hydrophobic signal peptide) at its amino terminal that transports the growing polypeptide into the lumen of the Endoplasmic Reticulum. Once inside the ER, this signal peptide is cleaved by a signal peptidase.

<span style="color:Brown">'''<scene name='Factor_IX/Ixstructure/4'>Factor IX</scene>'''</span> ('''plasma thromboplastin component''', '''Christmas factor''', or '''hemophilia B factor''') is a 57-kDa vitamin K-dependent procoagulant glycoprotein. It is synthesized by the liver hepatocyte as a [[pre-prozymogen]] that requires extensive posttranslational modification<ref>PMID:2169923</ref>. The [[pre-prozymogen]] contains a pre-peptide (hydrophobic signal peptide) at its amino terminal that transports the growing polypeptide into the lumen of the Endoplasmic Reticulum. Once inside the ER, this signal peptide is cleaved by a signal peptidase.

A [[pro-peptide]] functions as a recognition element for a vitamin K-dependent carboxylase (γ-glutamyl carboxylase) which modifies 12 glutamic acid residues to gamma-carboxyglutamyl (<scene name='Factor_IX/Ixstructure_residue/3'>Gla</scene>) residues<ref>PMID:12554099</ref>. These residues are required for the association with the anionic phospholipid surface through Ca2+-dependent binding. Additional details in [[Calcium ions the Gla domain]].

Factor IX: Difference between revisions

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 <StructureSection load='3lc3' size='450' side='right' scene='' caption=''>
-<span style="color:Brown">'''<scene name='Factor_IX/Ixstructure/4'>Factor IX</scene>'''</span> (plasma thromboplastin component, Christmas factor, or hemophilia B factor) is a 57-kDa vitamin K-dependent procoagulant glycoprotein. It is synthesized by the liver hepatocyte as a [[pre-prozymogen]] that requires extensive posttranslational modification<ref>PMID:2169923</ref>. The [[pre-prozymogen]] contains a pre-peptide (hydrophobic signal peptide) at its amino terminal that transports the growing polypeptide into the lumen of the Endoplasmic Reticulum. Once inside the ER, this signal peptide is cleaved by a signal peptidase.
+<span style="color:Brown">'''<scene name='Factor_IX/Ixstructure/4'>Factor IX</scene>'''</span> ('''plasma thromboplastin component''', '''Christmas factor''', or '''hemophilia B factor''') is a 57-kDa vitamin K-dependent procoagulant glycoprotein. It is synthesized by the liver hepatocyte as a [[pre-prozymogen]] that requires extensive posttranslational modification<ref>PMID:2169923</ref>. The [[pre-prozymogen]] contains a pre-peptide (hydrophobic signal peptide) at its amino terminal that transports the growing polypeptide into the lumen of the Endoplasmic Reticulum. Once inside the ER, this signal peptide is cleaved by a signal peptidase.
 A [[pro-peptide]] functions as a recognition element for a vitamin K-dependent carboxylase (γ-glutamyl carboxylase) which modifies 12 glutamic acid residues to gamma-carboxyglutamyl (<scene name='Factor_IX/Ixstructure_residue/3'>Gla</scene>) residues<ref>PMID:12554099</ref>. These residues are required for the association with the anionic phospholipid surface through Ca2+-dependent binding. Additional details in [[Calcium ions the Gla domain]].