Sandbox Reserved 1121: Difference between revisions

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=== PC binding site ===

PC stands for phosphocholine. It is a phospholipid in cell membranes and a plasma lipoproteins.<ref name="thompson">Thompson, D., Pepys, M. B., Wood, S. P. (1999), The physiological structure of human C-reactive protein and its complex with phosphocholine, Structure February 1999, 7:169–177.</ref> Phe-66 and Glu-81 are the two key residues that enable the binding of PC. <ref name="kumar"/> They interact with the choline function of PC, which therefore lies inside the PC-binding site. ~~<ref name="agrawal"/>~~

PC stands for phosphocholine. It is a phospholipid in cell membranes and a plasma lipoproteins.<ref name="thompson">Thompson, D., Pepys, M. B., Wood, S. P. (1999), The physiological structure of human C-reactive protein and its complex with phosphocholine, Structure February 1999, 7:169–177.</ref> Phe-66 and Glu-81 are the two key residues that enable the binding of PC. <ref name="kumar"/> They interact with the choline function of PC, which therefore lies inside the PC-binding site.

CRP binds the phosphocholine and other ligands in a Ca2+-dependent way. The PC-binding site is next to the Ca2+-binding sites on the same face of the CRP protein. Th PC-binding site is a hydrophobic pocket constituted by the residues Leu64, Phe66, Thr76 and the two Ca2+. The phosphate groupe of PC interacts by coordination with the two Ca2+. <ref name="agrawal"/>

CRP binds the phosphocholine and other ligands in a Ca2+-dependent way. The PC-binding site is next to the Ca2+-binding sites on the same face of the CRP protein. Th PC-binding site is a hydrophobic pocket constituted by the residues Leu64, Phe66, Thr76 and the two Ca2+. The phosphate groupe of PC interacts by coordination with the two Ca2+.

CRP can also bind chromatin, histones, small nuclear robonucleoproteins nuclear envelop proteins and nucleosomes Ca2+-dependently. <ref name="agrawal"/>

== Function ==

CRP binds to PC located on the surface of bacteria that infected the organism. The resulting immune response is the phygocytosis of PC-expressing bacteria. <ref name="agrawal"/>

== Biomedical interest ==

Sandbox Reserved 1121: Difference between revisions

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@@ Line 18: / Line 18: @@
 === PC binding site ===
-PC stands for phosphocholine. It is a phospholipid in cell membranes and a plasma lipoproteins.<ref name="thompson">Thompson, D., Pepys, M. B., Wood, S. P. (1999), The physiological structure of human C-reactive protein and its complex with phosphocholine, Structure February 1999, 7:169–177.</ref> Phe-66 and Glu-81 are the two key residues that enable the binding of PC. <ref name="kumar"/> They interact with the choline function of PC, which therefore lies inside the PC-binding site. <ref name="agrawal"/>
+PC stands for phosphocholine. It is a phospholipid in cell membranes and a plasma lipoproteins.<ref name="thompson">Thompson, D., Pepys, M. B., Wood, S. P. (1999), The physiological structure of human C-reactive protein and its complex with phosphocholine, Structure February 1999, 7:169–177.</ref> Phe-66 and Glu-81 are the two key residues that enable the binding of PC. <ref name="kumar"/> They interact with the choline function of PC, which therefore lies inside the PC-binding site.
-CRP binds the phosphocholine and other ligands in a Ca<sup>2+</sup>-dependent way. The PC-binding site is next to the Ca<sup>2+</sup>-binding sites on the same face of the CRP protein. Th PC-binding site is a hydrophobic pocket constituted by the residues Leu64, Phe66, Thr76 and the two Ca<sup>2+</sup>. The phosphate groupe of PC interacts by coordination with the two Ca<sup>2+</sup>. <ref name="agrawal"/>
+CRP binds the phosphocholine and other ligands in a Ca<sup>2+</sup>-dependent way. The PC-binding site is next to the Ca<sup>2+</sup>-binding sites on the same face of the CRP protein. Th PC-binding site is a hydrophobic pocket constituted by the residues Leu64, Phe66, Thr76 and the two Ca<sup>2+</sup>. The phosphate groupe of PC interacts by coordination with the two Ca<sup>2+</sup>.
+CRP can also bind chromatin, histones, small nuclear robonucleoproteins nuclear envelop proteins and nucleosomes Ca<sup>2+</sup>-dependently. <ref name="agrawal"/>
 == Function ==
+CRP binds to PC located on the surface of bacteria that infected the organism. The resulting immune response is the phygocytosis of PC-expressing bacteria. <ref name="agrawal"/>
 == Biomedical interest ==