2n6i: Difference between revisions

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'''Unreleased structure'''
==NMR structure for a 2-stranded parallel beta-sheet==
<StructureSection load='2n6i' size='340' side='right' caption='[[2n6i]], [[NMR_Ensembles_of_Models | 10 NMR models]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2n6i]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2N6I OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2N6I FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=4FU:(1R,2S)-CYCLOHEXANE-1,2-DICARBOXYLIC+ACID'>4FU</scene>, <scene name='pdbligand=NH2:AMINO+GROUP'>NH2</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2n4n|2n4n]], [[2n6h|2n6h]]</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2n6i FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2n6i OCA], [http://pdbe.org/2n6i PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2n6i RCSB], [http://www.ebi.ac.uk/pdbsum/2n6i PDBsum]</span></td></tr>
</table>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
We have examined whether parallel beta-sheet secondary structure becomes more stable as the number of beta-strands increases, via comparisons among peptides designed to adopt two- or three-stranded parallel beta-sheet conformations in aqueous solution. Our three-strand design is the first experimental model of a triple-stranded parallel beta-sheet. Analysis of the designed peptides by nuclear magnetic resonance (NMR) and circular dichroism (CD) spectroscopy supports the hypothesis that increasing the number of beta-strands, from two to three, increases the stability of the parallel beta-sheet. We present the first experimental evidence for cooperativity in the folding of a triple-stranded parallel beta-sheet, and we show how minimal model systems may enable experimental documentation of characteristic properties, such as CD spectra, of parallel beta-sheets.


The entry 2n6i is ON HOLD  until Paper Publication
Impact of Strand Number on Parallel beta-Sheet Stability.,Kung VM, Cornilescu G, Gellman SH Angew Chem Int Ed Engl. 2015 Nov 23;54(48):14336-9. doi: 10.1002/anie.201506448. , Epub 2015 Oct 12. PMID:26457984<ref>PMID:26457984</ref>


Authors: Kung, V.M., Cornilescu, G., Gellman, S.H.
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 
</div>
Description: NMR structure for a 2-stranded parallel beta-sheet
<div class="pdbe-citations 2n6i" style="background-color:#fffaf0;"></div>
[[Category: Unreleased Structures]]
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Cornilescu, G]]
[[Category: Cornilescu, G]]
[[Category: Kung, V.M]]
[[Category: Gellman, S H]]
[[Category: Gellman, S.H]]
[[Category: Kung, V M]]
[[Category: De novo protein]]
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