Sandbox Reserved 1121: Difference between revisions
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=== PC binding site === | === PC binding site === | ||
PC stands for phosphocholine. It is a phospholipid in cell membranes and a plasma lipoproteins <ref name="thompson"/>. | PC stands for phosphocholine. It is a phospholipid in cell membranes and a plasma lipoproteins <ref name="thompson"/>. The PC-binding site is a hydrophobic pocket constituted by the residues Leu64, Phe66, Thr76 and the two Ca<sup>2+</sup> <ref name="agrawal"/>. | ||
The choline function of PC interacts with the two key residues Phe-66, therefore PC lies inside the PC-binding site <ref name="kumar"/> <ref name="agrawal"/>. | |||
The PC-binding site is next to the Ca<sup>2+</sup>-binding sites on the same face of the CRP protein. The phosphate groupe of PC interacts by coordination with the two Ca<sup>2+</sup> <ref name="agrawal"/>. | |||
The affinity of CRP for PC increases with the concentration of PC. A surface containing a high density of PC, such as C-polycaccharide, is therefore propitious to the CRP-binding <ref name="duclos"/>. | The affinity of CRP for PC increases with the concentration of PC. A surface containing a high density of PC, such as C-polycaccharide, is therefore propitious to the CRP-binding <ref name="duclos"/>. | ||
CRP can also bind chromatin, histones, small nuclear | CRP can also bind chromatin, histones, small nuclear ribonucleoproteins nuclear envelop proteins and nucleosomes Ca<sup>2+</sup>-dependently <ref name="agrawal"/>. | ||
[[Image:Phosphocholine.PNG | thumb | PC and Ca<sup>2+</sup>-binding site <ref>The PyMOL Molecular Graphics System, Version 1.8 Schrödinger, LLC.</ref>]] | [[Image:Phosphocholine.PNG | thumb | PC and Ca<sup>2+</sup>-binding site <ref>The PyMOL Molecular Graphics System, Version 1.8 Schrödinger, LLC.</ref>]] | ||
