Sandbox Reserved 1121: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Lucile Guyot (talk | contribs) No edit summary |
Lucile Guyot (talk | contribs) No edit summary |
||
| Line 27: | Line 27: | ||
=== PC binding site === | === PC binding site === | ||
PC stands for phosphocholine. It is a phospholipid in cell membranes and a plasma | PC stands for phosphocholine. It is a phospholipid in cell membranes and a plasma lipoprotein <ref name="thompson"/>. The PC-binding site is a hydrophobic pocket constituted by the residues Leu64, Phe66, Thr76 and the two Ca<sup>2+</sup> <ref name="agrawal"/>. | ||
The choline function of PC interacts with the two key residues Phe-66, therefore PC lies inside the PC-binding site <ref name="kumar"/> <ref name="agrawal"/>. | The choline function of PC interacts with the two key residues Phe-66 and Glu-81, therefore PC lies inside the PC-binding site <ref name="kumar"/> <ref name="agrawal"/>. | ||
The PC-binding site is next to the Ca<sup>2+</sup>-binding sites on the same face of the CRP protein. The phosphate groupe of PC interacts by coordination with the two Ca<sup>2+</sup> <ref name="agrawal"/>. | The PC-binding site is next to the Ca<sup>2+</sup>-binding sites on the same face of the CRP protein. The phosphate groupe of PC interacts by coordination with the two Ca<sup>2+</sup> <ref name="agrawal"/>. | ||
The affinity of CRP for PC increases with the concentration of PC. A surface containing a high density of PC, such as C-polycaccharide, is therefore propitious to the CRP-binding <ref name="duclos"/>. | The affinity of CRP for PC increases with the concentration of PC. A surface containing a high density of PC, such as C-polycaccharide, is therefore propitious to the CRP-binding <ref name="duclos"/>. | ||
