Sandbox Reserved 1121: Difference between revisions
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Tertiary and quaternary structure: | Tertiary and quaternary structure: | ||
Like SAP, the protein consists of five protomers, uncovalently bonded and nonglycosylated that are arranged symmetrically around a central pore <ref name="Volanakis">PMID: 11532280</ref> <ref name="duclos"/>. | |||
The diameter of the CRP pentamer is 102 Å, the inner pore diameter is 30 Å and the diameter of a subunit is 36 Å <ref name="agrawal">PMID: 19799114 </ref>. | The diameter of the CRP pentamer is 102 Å, the inner pore diameter is 30 Å and the diameter of a subunit is 36 Å <ref name="agrawal">PMID: 19799114 </ref>. | ||
Thereafter, the ligand-binding face of the molecule will be called B and the opposite face will be called A. The B face binds two Ca<sup>2+</sup> ions and a phosphocholine per subunit. The A face, recognizable by the presence of an α-helix and a deep cavity, can interact with C1q and Fc receptors <ref name="duclos">PMID: 15531769 </ref>. | Thereafter, the ligand-binding face of the molecule will be called B and the opposite face will be called A. The B face binds two Ca<sup>2+</sup> ions and a phosphocholine per subunit. The A face, recognizable by the presence of an α-helix and a deep cavity, can interact with C1q and Fc receptors <ref name="duclos">PMID: 15531769 </ref>. | ||
