Sandbox Reserved 1120: Difference between revisions

Revision as of 22:27, 27 January 2016 view source Fantin Mesny (talk \| contribs) 84 edits No edit summary ← Older edit		Revision as of 22:30, 27 January 2016 view source Fantin Mesny (talk \| contribs) 84 edits No edit summary Newer edit →
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	=== De La Chapelle syndrome (AKA XX male syndrome) :===		=== De La Chapelle syndrome (AKA XX male syndrome) :===

	From the meiosis just described would also result an abnormal X chromosome, carrying the SRY gene. If the sperm cell owning this chromosome fecundates an ovule, the resulting newborn will have a XX karyotype but a male phenotype. This is called the « De La Chapelle syndrome ». In this case, the patient can either develop testis or both testis and ovarian tissues. As some epigenetic mechanisms can inactivate the X chromosome carrying SRY, this syndrome ~~often~~ keeps the ~~patient~~ sterile.<ref>PMID: 4622299</ref>		From the meiosis just described would also result an abnormal X chromosome, carrying the SRY gene. If the sperm cell owning this chromosome fecundates an ovule, the resulting newborn will have a XX karyotype but a male phenotype. This is called the « De La Chapelle syndrome ». In this case, the patient can either develop testis or both testis and ovarian tissues. As some epigenetic mechanisms can inactivate the X chromosome carrying SRY, this syndrome keeps most of the patients sterile.<ref>PMID: 4622299</ref>

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