Sandbox Reserved 1120: Difference between revisions

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The interaction between the HMG-Box and DNA is specific and stable. It permits the bend of DNA (?75°). It is mostly hydrophobic interaction. Only one molecule of water interface the Box and the DNA. the complex is stabilized by salt bridges between positive charged residues of the HMG domain and negative charged phosphates.<ref>PMID: 9626701</ref>
The interaction between the HMG-Box and DNA is specific and stable. It permits the bend of DNA (?75°). It is mostly hydrophobic interaction. Only one molecule of water interface the Box and the DNA. the complex is stabilized by salt bridges between positive charged residues of the HMG domain and negative charged phosphates.<ref>PMID: 9626701</ref>


[[https://commons.wikimedia.org/wiki/File:HHMG_-_linear.svg Linear structure of hHMG-SRY]]
[[Media:HHMG-SRY.pdf]]
[[Image:HHMG - linear.svg]]
[[Media:HHMG - linear.svg]]
[[File:HHMG - linear.svg|HHMG - linear]]


The binding of SRY to DNA is specific. The DNA target site is a DNA octamer :
The binding of SRY to DNA is specific. The DNA target site is a DNA octamer :


5Õ d(CCTÕÕÕGCACAAACÕÕÕACC).
(5'-dGCACAAAC)
5Õ d(GGTÕÕÕGTTTGTGCÕÕÕAGG).
(5'-dGTTTGTGC)


This sequenece is found in the promoters of genes expressed during the testicular development
This sequenece is found in the promoters of genes expressed during the testicular development
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