Sandbox Reserved 1121: Difference between revisions

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=== Phosphocholine-binding site ===

PC stands for phosphocholine. It is a phospholipid in cell membranes and a plasma lipoprotein <ref name="~~thompson~~"/>. The PC-binding site is a hydrophobic pocket constituted by the residues Leu64, Phe66, Thr76 and the two Ca2+ <ref name="agrawal"/>.

PC stands for phosphocholine. It is a phospholipid in cell membranes and a plasma lipoprotein <ref name="Thompson"/>. The PC-binding site is a hydrophobic pocket constituted by the residues Leu64, Phe66, Thr76 and the two Ca2+ <ref name="agrawal"/>.

The choline function of PC interacts with the two key residues Phe66 and Glu81, therefore PC lies inside the PC-binding site <ref name="kumar"/> <ref name="agrawal"/>.

The PC-binding site is next to the Ca2+-binding sites on the same face of the CRP protein. The phosphate groupe of PC interacts by coordination with the two Ca2+ <ref name="agrawal"/>.

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== Biomedical interest ==

Healthy humans have a CRP rate which is generally about 1 μg/mL<ref name="kumar"/>. CRP is secreted by the liver into the blood circulation<ref name = "Alex"/>. CRP level is 1000 times higher in a cytokine-mediated response due to tissue injury, infection and inflammation. Therefore the CRP rate in serum is common use to detect the activity of a disease<ref name="~~thompson~~" />. CRP can be defined as a target for the development of cardioprotection and neuroprotection<ref name="kumar"/>.

Healthy humans have a CRP rate which is generally about 1 μg/mL<ref name="kumar"/>. CRP is secreted by the liver into the blood circulation<ref name = "Alex"/>. CRP level is 1000 times higher in a cytokine-mediated response due to tissue injury, infection and inflammation. Therefore the CRP rate in serum is common use to detect the activity of a disease<ref name="Thompson" />. CRP can be defined as a target for the development of cardioprotection and neuroprotection<ref name="kumar"/>.

== Structural highlights ==

Sandbox Reserved 1121: Difference between revisions

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@@ Line 29: / Line 29: @@
 === Phosphocholine-binding site ===
-PC stands for phosphocholine. It is a phospholipid in cell membranes and a plasma lipoprotein <ref name="thompson"/>. The PC-binding site is a hydrophobic pocket constituted by the residues Leu64, Phe66, Thr76 and the two Ca<sup>2+</sup> <ref name="agrawal"/>.
+PC stands for phosphocholine. It is a phospholipid in cell membranes and a plasma lipoprotein <ref name="Thompson"/>. The PC-binding site is a hydrophobic pocket constituted by the residues Leu64, Phe66, Thr76 and the two Ca<sup>2+</sup> <ref name="agrawal"/>.
 The choline function of PC interacts with the two key residues Phe66 and Glu81, therefore PC lies inside the PC-binding site <ref name="kumar"/> <ref name="agrawal"/>.
 The PC-binding site is next to the Ca<sup>2+</sup>-binding sites on the same face of the CRP protein. The phosphate groupe of PC interacts by coordination with the two Ca<sup>2+</sup> <ref name="agrawal"/>.
@@ Line 40: / Line 40: @@
 == Biomedical interest ==
-Healthy humans have a CRP rate which is generally about 1 μg/mL<ref name="kumar"/>. CRP is secreted by the liver into the blood circulation<ref name = "Alex"/>. CRP level is 1000 times higher in a cytokine-mediated response due to tissue injury, infection and inflammation. Therefore the CRP rate in serum is common use to detect the activity of a disease<ref name="thompson" />. CRP can be defined as a target for the development of cardioprotection and neuroprotection<ref name="kumar"/>.
+Healthy humans have a CRP rate which is generally about 1 μg/mL<ref name="kumar"/>. CRP is secreted by the liver into the blood circulation<ref name = "Alex"/>. CRP level is 1000 times higher in a cytokine-mediated response due to tissue injury, infection and inflammation. Therefore the CRP rate in serum is common use to detect the activity of a disease<ref name="Thompson" />. CRP can be defined as a target for the development of cardioprotection and neuroprotection<ref name="kumar"/>.
 == Structural highlights ==