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| '''Bacteriorhodopsin''' (Br) is a membrane protein in Archaea which moves protons across the cell membrane. | | '''Bacteriorhodopsin''' (Br) is a membrane protein in Archaea which moves protons across the cell membrane. See also [[Bacteriorhodopsin (Hebrew)]]. |
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| == Structural highlights == | | == Structural highlights == |
Revision as of 10:30, 28 January 2016
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Function
Bacteriorhodopsin (Br) is a membrane protein in Archaea which moves protons across the cell membrane. See also Bacteriorhodopsin (Hebrew).
Structural highlights
Br is composed of 6 α-helical elements each containing a retinal molecule. The retinal changes its ground state conformation upon binding of a proton, causing the Br to change conformation to the activated state and pump the proton. The retinal interacts predominantly with hydrophobic and aromatic residues [1] (Hydrophobic, Polar).
- ↑ Joh NH, Oberai A, Yang D, Whitelegge JP, Bowie JU. Similar energetic contributions of packing in the core of membrane and water-soluble proteins. J Am Chem Soc. 2009 Aug 12;131(31):10846-7. PMID:19603754 doi:10.1021/ja904711k
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3D Structures of bacteriorhodopsin
Updated on 28-January-2016
{"openlevels":0}
- Bacteriorhodopsin
- Bacteriorhodopsin (Hebrew), 3nsb, 3mbv, 1x0s, 1x0i, 1x0k, 1xji, 1iw6, 4fpd, 2i1x, 1kme, 1qm8, 1bm1, 1brr, 2brd, 4hyx– HsBr residues 14-261 + lipid + retinal – Halobacterium salinarum
- 3vhz - HsBr (mutant) + lipid + retinal
- 2wjk, 2wjl - HsBr residues 14-261 (mutant) + lipid + retinal
- 3han, 2hao, 3hap, 3haq, 3har, 3has, 3coc, 3cod, 1tn5, 1tn0, 1s51, 1s52, 1s53, 1s54, 1q5i, 1q5j, 1pxr, 1pxs, 3hao, 3utv, 3utw, 3utx, 3uty - HsBr residues 14-261 (mutant) + retinal
- 2ntu, 1py6, 1fbb, 1fbk, 1brx, 1ap9, 1at9 - HsBr residues 14-261 + retinal
- 4x31, 4x32 - HsBr residues 14-261 + lipid + retinal
- 2at9 - HsBr residues 14-261 + lipid + retinal – Cryo EM
- 1brd - HsBr residues 14-261 + retinal – Cryo EM
- 1s8j, 3t45 - HsBr residues 14-261 (mutant) + lipid + NO3 + retinal
- 1mgy - HsBr residues 14-261 (mutant) + lipid + Br + retinal
- 1s8l - HsBr residues 14-261 (mutant) + lipid + retinal
- 4md1, 4md2, 4ov0 - HsBr residues 14-261 + lipid
- 1qhj - HsBr residues 14-261 + phytanyl derivavative + retinal
- 4hwl – HsBr + heptane + hexane + retinal
- 1r84, 1r2n - HsBr residues 1-232 + retinal – NMR
- 1bct - HsBr residues 163-231 – NMR
- 1bha, 1bhb - HsBr residues 1-71 - NMR
- 1l0m – Br (mutant) – Halobacterium halobium - NMR
- 4pxk - Br (mutant) – Haloarcula marismortuim
- Bacteriorhodopsin intermediates
- 1f50, 1c8r - HsBr-BR residues 18-244 (mutant) + lipid + retinal
- 1c3w - HsBr-BR residues 5-231 + lipid + retinal
- 2zfe – HsBr-K residues 14-261 + lipid + retinal
- 1m0k, 1m0l, 1ixf - HsBr-K residues 1-261 + lipid + retinal
- 1m0m - HsBr-M1 residues 1-261 + lipid + retinal
- 1e0p, 2ntw, 1vjm - HsBr-L residues 18-245 + retinal
- 1ucq, 1iw9, 1o0a – HsBr-L residues 14-261 + lipid + retinal
- 1kg8, 1kg9, 1kgb, 1dze, 1cwq, 2zzl, 2i20, 2i21, 1p8h - HsBr-M residues 13-243 + lipid + retinal
- 1f4z, 1c8s, 1p8i - HsBr-M residues 18-244 (mutant) + lipid + retinal
- 1p8u – HsBr-N residues 14-261 (mutant) + lipid + retinal
- 1jv6, 1jv7, 3vi0 - HsBr-O residues 1-261 (mutant) + lipid + retinal
- 1qko, 1qkp - HsBr residues 14-261 + retinal
- Halorhodopsin
- 3abw, 3a7k, 3vvk – NpBr+ N3 + bacterioruberin + detergent + retinal – Natronomonas pharaonis
- 3qbg, 3qbi, 3qbk, 3qbl - NpBr + bacterioruberin + detergent + retinal
- 2jaf, 2jag, 1e12 - HsBr (mutant) + lipid+ retinal
- Sensory rhodopsin II
- 2ksy – NpBr – NMR
- 2f93, 2f95, 1h2s - BpBr + Br transducer + detergent + retinal
- 3qap, 3qdc - NpBr + eicosane + lipid + retinal
- 4gyc - NpBr + retinal + eicosane + lipid + Br transducer
- 1gu8, 1gue, 1h68, 1jgj - NpBr + retinal
- 1xio - AnBr + detergent + retinal - Anabaena
- 4tl3 - AnBr (mutant) + detergent + retinal
- 2m3g - AnBr + detergent - NMR
- Xanthorhodopsin
- 3ddl – Br + detergent + salinixanthin + retinal – Salinibacter ruber
- Archaerhodopsin
- 2ei4, 2z55 – HaBr + bacterioruberin + detergent + retinal – Halobacterium
- 1vgo - HaBr + detergent + retinal
- 1uaz - HaBr + retinal
See Also
References
