Sandbox Reserved 1123: Difference between revisions

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J. Virol. May 2010 vol. 84 no. 10 5181-5190]</ref>
J. Virol. May 2010 vol. 84 no. 10 5181-5190]</ref>


* Nuclear pore (certainly but not sure)<ref>[http://www.google.fr/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&ved=0ahUKEwiV2fr01MzKAhWLhhoKHafGDaUQFggiMAA&url=http%3A%2F%2Fwww.nature.com%2Fnrmicro%2Fjournal%2Fv13%2Fn8%2Ffull%2Fnrmicro3503.html&usg=AFQjCNHxI2ZQfqG9K9oGRGsoomYd40gcgw HIV-1 capsid: the multifaceted key player in HIV-1 infection Nature Reviews Microbiology 13,471–483 (2015)doi:10.1038/nrmicro3503]</ref>
* Nuclear pore (certainly but not sure)<ref name="A">[http://www.google.fr/url?sa=t&rct=j&q=&esrc=s&source=web&cd=1&ved=0ahUKEwiV2fr01MzKAhWLhhoKHafGDaUQFggiMAA&url=http%3A%2F%2Fwww.nature.com%2Fnrmicro%2Fjournal%2Fv13%2Fn8%2Ffull%2Fnrmicro3503.html&usg=AFQjCNHxI2ZQfqG9K9oGRGsoomYd40gcgw HIV-1 capsid: the multifaceted key player in HIV-1 infection Nature Reviews Microbiology 13,471–483 (2015)doi:10.1038/nrmicro3503]</ref>
* Dynein
* Dynein
* Integrase ?  
* Integrase ?  
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<Structure load='2XDE' size='300' frame='false' align='left' caption='Cristal structure of PF-3450074 with N terminal domain of HIV capsid PDB:2XDE' scene='Insert optional scene name here' />'
<Structure load='2XDE' size='300' frame='false' align='left' caption='Cristal structure of PF-3450074 with N terminal domain of HIV capsid PDB:2XDE' scene='Insert optional scene name here' />'


Thank to its central role in viral infectious process (genome protection, enveloppe cohesion, uncoating, budding), HIV capsid is a very good target for antiviral drugs. As a result, many research teams are working in this way and some molecules such as PF-3450074 are very promising.  
Thank to its central role in viral infectious process (genome protection, enveloppe cohesion, uncoating, budding), HIV capsid is a very good target for antiviral drugs. As a result, many research teams are working in this way and some molecules such as PF-3450074 <ref name="A"/> are very promising.  
By binding to a "central pocket" on P24, it was shown ''in vitro'' that this compound is inhibiting the new viruses assembly, and consequently the virus budding.
By binding to a "central pocket" on P24, it was shown ''in vitro'' that this compound is inhibiting the new viruses assembly, and consequently the virus budding.


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<references />
<references />
Structural capsid image : By Thomas Splettstoesser (www.scistyle.com) (Own work) [CC BY-SA 4.0 (http://creativecommons.org/licenses/by-sa/4.0)], via Wikimedia Commons
Structural capsid image : By Thomas Splettstoesser (www.scistyle.com) (Own work) [CC BY-SA 4.0 (http://creativecommons.org/licenses/by-sa/4.0)], via Wikimedia Commons
'''Nuclear import :'''
HIV-1 capsid: the multifaceted key player in HIV-1 infection Nature Reviews Microbiology 13,471–483 (2015)doi:10.1038/nrmicro3503


'''Capsid targeting drug'''
'''Capsid targeting drug'''


Edward M. Campbell & Thomas J. Hope. HIV-1 capsid: the multifaceted key player in HIV-1 infection Nature Reviews Microbiology 13,471–483 (2015)doi:10.1038/nrmicro3503 Published online 16 July 2015
Edward M. Campbell & Thomas J. Hope. HIV-1 capsid: the multifaceted key player in HIV-1 infection Nature Reviews Microbiology 13,471–483 (2015)doi:10.1038/nrmicro3503 Published online 16 July 2015
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