Sandbox Reserved 1125: Difference between revisions
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[http://www.jleukbio.org/content/81/4/870.full] | [http://www.jleukbio.org/content/81/4/870.full] | ||
This domain is localized outside of the catalytic domain. It is essential for the substrate recognition of MMP-8 | This domain is localized outside of the catalytic domain. It is essential for the substrate recognition of MMP-8 and the single catalytic domain of MMP-8 is not able to cleave collagen. When this hemopexin-like domain is removed, the protein loses its ability to cleave collagen. However, neutrophil collagenase is still able to cleave other substrate. | ||
It seems that the collagen binds to two sites on MMP-8 : one in the catalytic site and another in the hemopexin domain. One hypothesis is that when the collagen binds to both sites, its helical structure is destabilized and unwound. Thus, the cleavage site of collagen is accessible and the cleavage reaction can occur. | |||
