Sandbox Reserved 1122: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
{{Sandbox_Reserved_ESBS_2015}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | {{Sandbox_Reserved_ESBS_2015}}<!-- PLEASE ADD YOUR CONTENT BELOW HERE --> | ||
==HUMAN BCL-2, ISOFORM1== | ==HUMAN BCL-2, ISOFORM1== | ||
<StructureSection load='1g5m' size='400' side='right' caption='3D STRUCTURE OF HUMAN BCL-2, ISOFORM1 (from residue 3 to 207) BASED ON NMR SPECTROSCOPY' scene=''> | <StructureSection load='1g5m' size='400' side='right' caption='3D STRUCTURE OF HUMAN BCL-2, ISOFORM1 (from residue 3 to 207) BASED ON NMR SPECTROSCOPY' scene='71/719863/Scenebcl2/1'> | ||
Human Bcl-2 (B-Cell Lymphoma 2), isoform 1 is an oncoprotein of 239 residues regulating cell death (apoptosis), notably acting as an anti-apoptotic. It is encoded by the ''BCL-2'' gene located on the 18th chromosome (63.12-63.32 Mb). There are 2 isoforms of this protein (𝛼 and 𝛽), produced by alternative splicing, and which differ by 2 aminoacids (residues 96 (A→T) and 110 (R→G))<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC30598/ Solution structure of the antiapoptotic protein bcl-2]</ref>. Alteration of this protein is a caused of many cancers, and is also likely to be involved in schyzophrenia and autoimmunity. | Human Bcl-2 (B-Cell Lymphoma 2), isoform 1 is an oncoprotein of 239 residues regulating cell death (apoptosis), notably acting as an anti-apoptotic. It is encoded by the ''BCL-2'' gene located on the 18th chromosome (63.12-63.32 Mb). There are 2 isoforms of this protein (𝛼 and 𝛽), produced by alternative splicing, and which differ by 2 aminoacids (residues 96 (A→T) and 110 (R→G))<ref>[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC30598/ Solution structure of the antiapoptotic protein bcl-2]</ref>. Alteration of this protein is a caused of many cancers, and is also likely to be involved in schyzophrenia and autoimmunity. | ||
