Sandbox Reserved 1120: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Fantin Mesny (talk | contribs) No edit summary |
Fantin Mesny (talk | contribs) No edit summary |
||
| Line 135: | Line 135: | ||
===Cathecolamines regulation=== | ===Cathecolamines regulation=== | ||
It has been shown SRY is present in brain regions and activate the Tyrosine-3-Hydroxylase expression. This enzyme catalyses the rate-limiting step of catecholamine synthesis (L-Tyrosine to L-DOPA). Furthermore, SRY also activate the expression of Monoamine Oxidase A which is responsible for the inactivation of catecholamines. Therefore, it regulates both positively and negatively the catecholamines concentration. | It has been shown SRY is present in brain regions and activate the Tyrosine-3-Hydroxylase expression. This enzyme catalyses the rate-limiting step of catecholamine synthesis (L-Tyrosine to L-DOPA). Furthermore, SRY also activate the expression of Monoamine Oxidase A which is responsible for the inactivation of catecholamines. Therefore, it regulates both positively and negatively the catecholamines concentration. <ref>PMID: 24604382</ref> | ||
===Other extra-testicular effects=== | |||
Some knock-down experiments have shown that SRY may also be a major actor in the dopamine pathway. On the peripheral side, it even regulates noradrenaline levels and blood pressure.<ref>PMID: 24604382</ref> A researcher who contributed to discovering this effects says it might explain why "the aggressive fight-or-flight reaction is more dominant in men, while women predominantly adopt a less aggressive tend-and-befriend response".<ref>Cohen, Tamara. The 'macho' gene that makes men behave aggressively has been found. The Daily Mail (2012). [http://www.dailymail.co.uk/sciencetech/article-2111668/The-macho-gene-makes-men-aggressive-found.html#ixzz3yZC2BV4k]</ref> | |||
