Sandbox Reserved 1123: Difference between revisions

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== Introduction ==

Since 2000, 38,1 million people were infected by the human immunodeficiency virus (HIV)<ref>[http://www.avert.org/professionals/hiv-around-world/global-statistics Global HIV and AIDS statistics]<ref/>.

This virus can cause the acquired immunodeficiency symptom (AIDS) which can often be lethal. The HIV belongs to the retrovirus family, more precisely to the lentivirus. This virus infects immune cells (T cells, macrophages, …) by integrating its genome in the host cell genome. Since HIV is a RNA virus, it converts its RNA into DNA thanks to the reverse transcriptase. Nevertheless, when its genome is integrated in the host genome, it can stay in latency during a long time.

The virus becomes active when the cell starts to fight another infection. The host cell transcript its own DNA and the viral DNA. This viral DNA codes for lytic proteins and viral proteins. The lytic proteins will kill the host cell, thus releasing the new viral particules. Indeed, it is the immune cells death which induces the decrease of the immune response and enhances thus the sensibility to other infections. Moreover, the viral proteins will produce new viruses which will be released and infect new cells. In this way, the knowledge of the different viral proteins, like the capsid proteins, can allows us to find new targets in order to avoid the viral dispersion/propagation ? <ref>[http://www.ncbi.nlm.nih.gov/pubmed/8493571 Weiss RA (May 1993). "How does HIV cause AIDS?". Science 260 (5112): 1273–9.Bibcode:1993 Science 260.1273W. doi:10.1126/science.8493571. PMID 8493571.]<ref/>

Sandbox Reserved 1123: Difference between revisions

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 == Introduction ==
+Since 2000, 38,1 million people were infected by the human immunodeficiency virus (HIV)<ref>[http://www.avert.org/professionals/hiv-around-world/global-statistics Global HIV and AIDS statistics]<ref/>.
+This virus can cause the acquired immunodeficiency symptom (AIDS) which can often be lethal. The HIV belongs to the retrovirus family, more precisely to the lentivirus. This virus infects immune cells (T cells, macrophages, …) by integrating its genome in the host cell genome. Since HIV is a RNA virus, it converts its RNA into DNA thanks to the reverse transcriptase. Nevertheless, when its genome is integrated in the host genome, it can stay in latency during a long time.
+The virus becomes active when the cell starts to fight another infection. The host cell transcript its own DNA and the viral DNA. This viral DNA codes for lytic proteins and viral proteins. The lytic proteins will kill the host cell, thus releasing the new viral particules. Indeed, it is the immune cells death which induces the decrease of the immune response and enhances thus the sensibility to other infections. Moreover, the viral proteins will produce new viruses which will be released and infect new cells. In this way, the knowledge of the different viral proteins, like the capsid proteins, can allows us to find new targets in order to avoid the viral dispersion/propagation ? <ref>[http://www.ncbi.nlm.nih.gov/pubmed/8493571 Weiss RA (May 1993). "How does HIV cause AIDS?". Science 260 (5112): 1273–9.Bibcode:1993 Science 260.1273W. doi:10.1126/science.8493571. PMID 8493571.]<ref/>