Sandbox Reserved 1122: Difference between revisions
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NALP1 is a member of a NLR-family proteins. Its function is to activate the members of the proinflammatory caspase family which participate in cytokine activation pathway (especially caspase-1). The Bcl-2 loop regions between the BH3 and BH4 bind NALP1. This interaction is exclusively reserved to two members of Bcl-2 family: Bcl-XL and Bcl-2 itself because this interacting region is highly variable in Bcl-2 family. By binding to NALP1, Bcl-2 inhibits the inflammatory caspase activation. Hence, it protects cell from the stress. | NALP1 is a member of a NLR-family proteins. Its function is to activate the members of the proinflammatory caspase family which participate in cytokine activation pathway (especially caspase-1). The Bcl-2 loop regions between the BH3 and BH4 bind NALP1. This interaction is exclusively reserved to two members of Bcl-2 family: Bcl-XL and Bcl-2 itself because this interacting region is highly variable in Bcl-2 family. By binding to NALP1, Bcl-2 inhibits the inflammatory caspase activation. Hence, it protects cell from the stress. | ||
The posttranslational modifications found on the loops between BH3 and BH4 modify the anti-apoptotic activity of Bcl-2. Hence, the Bcl-2 binding to NALP1 can be affected by these modifications. <ref>[http://www.sciencedirect.com/science/article/pii/S0092867407003042 Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1] </ref> | The posttranslational modifications found on the loops between BH3 and BH4 modify the anti-apoptotic activity of Bcl-2. Hence, the Bcl-2 binding to NALP1 can be affected by these modifications. <ref>[http://www.sciencedirect.com/science/article/pii/S0092867407003042 Bcl-2 and Bcl-XL Regulate Proinflammatory Caspase-1 Activation by Interaction with NALP1] </ref> | ||
=== Interaction with c-Myc === | |||
When Bcl-2 is anchored to nuclear membrane, it can interact with nuclear proteins, for example, transcription factors such as c-Myc. <scene name='71/719863/Scenelucas/1'>BH4</scene> domain of Bcl-2 binds MBII domain of c-Myc. This interaction has several consequences: increase of half-life of c-Myc and its transcriptional activity and inhibition of DNA repair (through down-regulation of AP endonuclease (APE1) expression). Interestingly, c-Myc can also be found in cytoplasm where it is able to interact with mitochondrial Bcl-2. | |||
== Diseases == | == Diseases == | ||
