Sandbox Reserved 1124: Difference between revisions
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<scene name='71/719865/C-terminal_sh3_domains/1'>The C-terminal SH3 domain</scene> goes from the amino acid 156 to 215. The role of this domain is little known. But it has been shown that, for a stable complex formation, the C-Terminal SH3 domain has to recognize a 13 residues sequence with the following motif: P-x-x-x-R-x-x-K-P. Sos contains this sequence, as well as Gab1, which also binds to Grb2. The interaction of Grb2 with Gab1 has been demonstrated with precipitation experiments. ref | <scene name='71/719865/C-terminal_sh3_domains/1'>The C-terminal SH3 domain</scene> goes from the amino acid 156 to 215. The role of this domain is little known. But it has been shown that, for a stable complex formation, the C-Terminal SH3 domain has to recognize a 13 residues sequence with the following motif: P-x-x-x-R-x-x-K-P. Sos contains this sequence, as well as Gab1, which also binds to Grb2. The interaction of Grb2 with Gab1 has been demonstrated with precipitation experiments. <ref >http://www.nature.com/onc/journal/v20/n9/full/1204202a.html</ref> | ||
In the Ras pathway, the Ct SH3 domain improves the overall stability of the Grb2-SOS complex.<ref >PMID:9383403</ref> | In the Ras pathway, the Ct SH3 domain improves the overall stability of the Grb2-SOS complex.<ref >PMID:9383403</ref> | ||
