Sandbox Reserved 1120: Difference between revisions
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==SRY gene== | ==SRY gene== | ||
The SRY gene encodes the SRY protein. The SRY protein is a transcriptional factor that induces the male phenotype in the embryo. The SRY gene is located on the [https://en.wikipedia.org/wiki/Y_chromosome Y chromosome] in the short arm (p) 11.3 <ref>[http://www.ncbi.nlm.nih.gov/gene/6736 NCBI gene]</ref>. This gene has only one exon that contains the HMG domain (DNA-binding High-Mobility Group box domain). It means that SRY mRNA does not have an alternative splicing, so there is only one isoforme of SRY protein<ref name | The SRY gene encodes the SRY protein. The SRY protein is a transcriptional factor that induces the male phenotype in the embryo. The SRY gene is located on the [https://en.wikipedia.org/wiki/Y_chromosome Y chromosome] in the short arm (p) 11.3 <ref>[http://www.ncbi.nlm.nih.gov/gene/6736 NCBI gene]</ref>. This gene has only one exon that contains the HMG domain (DNA-binding High-Mobility Group box domain). It means that SRY mRNA does not have an alternative splicing, so there is only one isoforme of SRY protein<ref name="McE"> McElreavey K, Barbaux S, Ion A, Fellous M. The genetic basis of murine and human sex determination: a review. Heredity. 1995 Dec;75 ( Pt 6):599–611. [http://www.ncbi.nlm.nih.gov/pubmed/8575930]</ref>. Moreover, the human genome contains only one copy of the SRY gene, whereas the mouse genome contains 6 copy of this gene<ref> Sekido R, Lovell-Badge R. Genetic control of testis development. Sex Dev Genet Mol Biol Evol Endocrinol Embryol Pathol Sex Determ Differ. 2013;7(1-3):21–32 </ref>. | ||
===Sequence of the SRY gene=== | ===Sequence of the SRY gene=== | ||
