Sandbox Reserved 1125: Difference between revisions
From Proteopedia
Jump to navigationJump to search
Laura Dutto (talk | contribs) No edit summary |
Laura Dutto (talk | contribs) No edit summary |
||
| Line 87: | Line 87: | ||
== Disease == | == Disease == | ||
=== knc === | === knc === | ||
Overexpression of MMP-8, or inadequate control by TIMPs, can be associated with a lot of pathological conditions<ref>[http://www.enzim.hu/~lbarna/articles/19173605.pdf "Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S1′ Subsite of Matrix Metalloproteinase 8"]</ref>. | Overexpression of MMP-8, or inadequate control by TIMPs, can be associated with a lot of pathological conditions<ref>[http://www.enzim.hu/~lbarna/articles/19173605.pdf "Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S1′ Subsite of Matrix Metalloproteinase 8"]</ref>. | ||
*psoriasis, sclerosis, osteoarthritis, rheumatoid arthritis, osteoporosis | *psoriasis, sclerosis, osteoarthritis, rheumatoid arthritis, osteoporosis | ||
*Alzheimer's disease | *Alzheimer's disease | ||
*tumor growh and metastasis | *tumor growh and metastasis | ||
*(MMP)-8 has been associated with the progression of periodontitis, a common inflammatory disease of the supporting structures of the teeth<ref>PMID:16928431</ref> | *(MMP)-8 has been associated with the progression of periodontitis, a common inflammatory disease of the supporting structures of the teeth<ref>PMID:16928431</ref> | ||
What makes this MMP unique is its exclusive pattern of expression in inflammatory conditions.<ref>PMID:9727011</ref> | |||
=== Therapeutic potential === | === Therapeutic potential === | ||
