Sandbox Reserved 1125: Difference between revisions
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=== knc === | === knc === | ||
Overexpression of MMP-8, or inadequate control by TIMPs, can be associated with a lot of pathological conditions<ref>[http://www.enzim.hu/~lbarna/articles/19173605.pdf "Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S1′ Subsite of Matrix Metalloproteinase 8"]</ref>. | Overexpression of MMP-8, or inadequate control by TIMPs, can be associated with a lot of pathological conditions<ref>[http://www.enzim.hu/~lbarna/articles/19173605.pdf "Extra Binding Region Induced by Non-Zinc Chelating Inhibitors into the S1′ Subsite of Matrix Metalloproteinase 8"]</ref>. | ||
*psoriasis, sclerosis, osteoarthritis, rheumatoid arthritis, osteoporosis | *Psoriasis: In patient with psoriasis, highly elevated levels of nitric oxide (NO) are released at the surface of psoriatic plaques. The peroxynitrite-dependent activation of the collagenase MMP-8 may induce the formation of extended rete pegs.<ref>PMID:11786028</ref> | ||
*sclerosis, osteoarthritis, rheumatoid arthritis, osteoporosis | |||
*Alzheimer's disease | *Alzheimer's disease | ||
*tumor growh and metastasis | *tumor growh and metastasis | ||
