Sandbox Reserved 1124: Difference between revisions
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The relevance of Grb2 has been enlightened thanks to studies on ''Caenorhabditis elegans''. Sem-5, an homologue of Grb2, was found to be implied in the Let-60 pathway, an homologue of Ras.<ref name="polyprolin"/> | The relevance of Grb2 has been enlightened thanks to studies on ''Caenorhabditis elegans''. Sem-5, an homologue of Grb2, was found to be implied in the Let-60 pathway, an homologue of Ras.<ref name="polyprolin"/> | ||
It was first discovered that Grb2 binds to EGFR. Then, eight successive studies showed that Grb2 makes the connection between EGFR and Sos, partly thanks to its SH3 domains. This discoveries enabled for a part to reveal that the subcellular location of signalling proteins plays an important role in the regulation of their function. Sos1 attaches to the plasma membrane after having been activated by Grb2, thus coming closer to Ras to activate it.<ref>PMID: 21686117</ref> | |||
== DNA/RNA == | == DNA/RNA == | ||
