1c4p: Difference between revisions
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
|DOMAIN= | |||
|RELATEDENTRY=[[1bml|1BML]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1c4p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1c4p OCA], [http://www.ebi.ac.uk/pdbsum/1c4p PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1c4p RCSB]</span> | |||
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[[Category: plasminogen activator]] | [[Category: plasminogen activator]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 19:14:25 2008'' | ||
Revision as of 16:14, 30 March 2008
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| 1c4p, resolution 2.4Å | |||||||||||||
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| Related: | 1BML
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| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
BETA DOMAIN OF STREPTOKINASE
Overview
Streptokinase, a 47 kDa secreted protein of hemolytic strains of streptococci, is a human plasminogen activator and contains three structural domains linked by flexible loops. We describe here the crystal structure of the isolated streptokinase middle (SKbeta) domain determined at 2.4 A resolution. Among the functionally important structural features is a putative binding site for a kringle domain of plasminogen located at the tip of a fully exposed hairpin loop. The distribution of genetically conserved residues of SKbeta is strongly correlated with their functions. The extensive interface of the SKbeta dimer suggests that such dimers may also exist in solution for free SKbeta.
About this Structure
1C4P is a Single protein structure of sequence from Streptococcus dysgalactiae subsp. equisimilis. Full crystallographic information is available from OCA.
Reference
Crystal structure of streptokinase beta-domain., Wang X, Tang J, Hunter B, Zhang XC, FEBS Lett. 1999 Oct 1;459(1):85-9. PMID:10508922
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